71459-50-2

Upstream product

• 71459-58-0 5'-O-(bis(4-methoxyphenyl)phenylmethyl)-P-(4-chlorophenyl)thymidylyl-(3'->5')-2'-deoxy-N-(2-methyl-1-oxopropyl)guanosine 3'-benzoate 
• 68892-41-1 5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine 
• 98-88-4 benzoyl chloride 
• 63660-23-1 3'-O-benzoyl-N²-isobutyryl-2'-deoxyguanosine 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 62420-37-5 (p-chlorophenyl) di(1,2,4-triazolido)phosphate 
• 93966-65-5 5'-O-(bis(4-methoxyphenyl)phenylmethyl)-2'-deoxy-N-(2-methyl-1-oxopropyl)guanosine 3'-benzoate 
• 71100-57-7 C₃₇H₃₅ClN₂O₁₀P^(1-) 
• 42926-80-7 5'-O-(4-monomethoxytrityl)-2'-deoxythymidine 
• 13388-88-0 4-chlorophenyl phosphate 
• 57777-76-1 O^5'-(4-methoxy-trityl)-[3']thymidylic acid mono-(2-chloro-phenyl) ester 

Downstream Products

• 90827-18-2 C₁₀₃H₉₅Cl₃N₁₅O₂₈P₃ 

Relevant academic research and scientific papers

Synthesis of Deoxyoligonucleotide Linker Fragments for Genetic Engineering Using Improved Preparative and Analytical Techniques

For studies on the expression of recombinant DNA, linker fragments have been prepared which serve to introduce specific points of cleavage on the DNA as well as the protein level.Such linkers were designed for cyanogen bromide as well as for collagenase cleavage of fused proteins.The preparation was done according to the triester synthesis scheme using improved and simpler routes to functionalized dinucleotide building blocks.Field desorption mass spectrometry was used as a routine tool for the identification and control of the purity of these units.

SYNTHESIS OF DEOXYRIBOOLIGONUCLEOTIDES BY USING AROMATIC PHOSPHORAMIDATES AS THE PROTECTING GROUP FOR THE 3'-PHOSPHO ENDS

p-Chlorophenyl phosphoranilidochloridate was used to phosphorylate the 3'-hydroxyl groups of N,5'-O-protected deoxyribonucleotides.These nucleotides served as the 3'-terminal unit in the syntheses of some protected oligonucleotides which were used in a bl