71897-59-1

Usage

Uses

Used in Pharmaceutical Industry:
2-(MORPHOLINOMETHYL)-PYRIDINE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with enhanced biological activities.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(MORPHOLINOMETHYL)-PYRIDINE is utilized as a component in the creation of agrochemicals, specifically for its potential as an antifungal and antibacterial agent, thereby aiding in the protection and enhancement of crop yields.
Safety Note:
Given its potentially hazardous nature, 2-(MORPHOLINOMETHYL)-PYRIDINE should be handled with care to prevent exposure and toxic effects, ensuring safety in both industrial and research applications.

InChI:InChI=1/C10H14N2O/c1-2-4-11-10(3-1)9-12-5-7-13-8-6-12/h1-4H,5-9H2

Upstream product

• 110-91-8 morpholine 
• 6959-47-3 2-chloromethylpyridine hydrochloride 
• 98-98-6 2-Picolinic acid 
• 112657-38-2 2-(N,N-penta-3-oxa-1,5-diyl-carboxamido)-pyridine 
• 5807-02-3 4-morpholinoacetonitrile 
• 74-86-2 acetylene 
• 1121-60-4 pyridine-2-carbaldehyde 

Downstream Products

• 123784-19-0 4-(phenyl(pyridin-2-yl)methyl)morpholine 
• 18212-96-9 1-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-2-morpholin-4-yl-2-phenyl-ethanone 
• 88675-40-5 1-(4-chlorophenyl)-2-morpholino-2-phenylethanone 
• 127029-79-2 2-morpholinyl-2-phenyl-1-(4-methylphenyl)-1-ethanone 

Relevant academic research and scientific papers

Thioglycerol-Stabilized Rhodium Nanoparticles in Biphasic Medium as Catalysts in Multistep Reactions

Small rhodium nanoparticles (ca. 3.5 nm) were prepared by the decomposition of an organometallic precursor under hydrogen pressure in glycerol using 1-thioglycerol as stabilizer. Full characterization in the solid state [HR-TEM, EDX, XPS] showed a fcc structure for the Rh0/RhI nanoparticles capped with thiolate ligand. Reduction of different functionalities, including nitro groups and imines, was applied to tandem reductive amination of aldehydes with primary and secondary amines, and to the synthesis of N-substituted anilines from nitrobenzene. In addition, thiolate-capped RhNPs could be recovered and reused up to 5 runs without loss of activity nor selectivity.

A practical catalytic reductive amination of carboxylic acids

We report reductive alkylation reactions of amines using carboxylic acids as nominal electrophiles. The two-step reaction exploits the dual reactivity of phenylsilane and involves a silane-mediated amidation followed by a Zn(OAc)2-catalyzed amide reduction. The reaction is applicable to a wide range of amines and carboxylic acids and has been demonstrated on a large scale (305 mmol of amine). The rate differential between the reduction of tertiary and secondary amide intermediates is exemplified in a convergent synthesis of the antiretroviral medicine maraviroc. Mechanistic studies demonstrate that a residual 0.5 equivalents of carboxylic acid from the amidation step is responsible for the generation of silane reductants with augmented reactivity, which allow secondary amides, previously unreactive in zinc/phenylsilane systems, to be reduced.

Palladium-Catalyzed Benzylic C-H Arylation of Azaarylmethylamines

A direct C-H functionalization approach to produce aryl(azaaryl)methylamines from azaarylmethylamines without directing groups is described. Under conditions where the azaarylmethylamines' C-H is reversibly deprotonated, a Pd(OAc)2/NIXANTPHOS-b

SYNTHESIS OF 2-AMINOMETHYLPYRIDINES FROM AMINONITRILES AND ACETYLENE

2-Aminomethylpyridines were synthesized from α-aminonitriles containing various substitutents at the α-carbon atom and acetylene at elevated pressures and temperatures in the presence of η5-dicyclopentadienylcobalt (cobaltocene) as catalyst.The

Anti-asthmatic, anti-allergic, anti-cholinergic, bronchodilator and anti-inflammatory 1-[(benzoylphenyl)-lower-alkyl]piperidines and analogs thereof

1-[(3- or 4-Benzoylphenyl)-lower-alkyl]-[(CH2)n --N=B]-substituted-piperidines, useful as anti-asthmatic, anti-allergic, anti-cholinergic, bronchodilator and anti-inflammatory agents, are prepared by alkylation of an appropriate subs

Benzoylphenyl lower alkanoyl piperidines

1-[(3- or 4-Benzoylphenyl)-lower-alkyl]-[(CH2)n -N=B]-substituted-piperidines, useful as anti-asthmatic, anti-allergic, anti-cholinergic, bronchodilator and anti-inflammatory agents, are prepared by alkylation of an appropriate subst