71897-59-1

Basic information

• Product Name: 2-(MORPHOLINOMETHYL)-PYRIDINE
• Synonyms: 2-(MORPHOLINOMETHYL)-PYRIDINE;4-(pyridin-2-ylmethyl)morpholine
• CAS NO: 71897-59-1
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 178.23
• Mol File: 71897-59-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 264.1°C at 760 mmHg
• Flash Point: 113.5°C
• Appearance: /
• Density: 1.113g/cm³
• Vapor Pressure: 0.00988mmHg at 25°C
• Refractive Index: 1.548
• CAS DataBase Reference: 2-(MORPHOLINOMETHYL)-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(MORPHOLINOMETHYL)-PYRIDINE(71897-59-1)
• EPA Substance Registry System: 2-(MORPHOLINOMETHYL)-PYRIDINE(71897-59-1)

Safety Data

• Hazardous Substances Data: 71897-59-1(Hazardous Substances Data)

Usage

General Description

2-(MORPHOLINOMETHYL)-PYRIDINE is a chemical compound with the molecular formula C9H12N2O. It is a heterocyclic compound containing a pyridine ring and a morpholine group, and is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. This chemical is known to have a wide range of biological activities and has been investigated for its potential as an antifungal and antibacterial agent. It is a colorless liquid at room temperature and has a molecular weight of 164.20 g/mol. 2-(MORPHOLINOMETHYL)-PYRIDINE is considered to be a potentially hazardous chemical and should be handled with caution to prevent exposure and toxic effects.

InChI:InChI=1/C10H14N2O/c1-2-4-11-10(3-1)9-12-5-7-13-8-6-12/h1-4H,5-9H2

Upstream product

• 5807-02-3 4-morpholinoacetonitrile 
• 74-86-2 acetylene 
• 110-91-8 morpholine 
• 6959-47-3 2-chloromethylpyridine hydrochloride 
• 98-98-6 2-Picolinic acid 
• 112657-38-2 2-(N,N-penta-3-oxa-1,5-diyl-carboxamido)-pyridine 
• 1121-60-4 pyridine-2-carbaldehyde 

Downstream Products

• 123784-19-0 4-(phenyl(pyridin-2-yl)methyl)morpholine 
• 18212-96-9 1-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-2-morpholin-4-yl-2-phenyl-ethanone 
• 88675-40-5 1-(4-chlorophenyl)-2-morpholino-2-phenylethanone 
• 127029-79-2 2-morpholinyl-2-phenyl-1-(4-methylphenyl)-1-ethanone 

Relevant articles and documents

A practical catalytic reductive amination of carboxylic acids

We report reductive alkylation reactions of amines using carboxylic acids as nominal electrophiles. The two-step reaction exploits the dual reactivity of phenylsilane and involves a silane-mediated amidation followed by a Zn(OAc)2-catalyzed amide reduction. The reaction is applicable to a wide range of amines and carboxylic acids and has been demonstrated on a large scale (305 mmol of amine). The rate differential between the reduction of tertiary and secondary amide intermediates is exemplified in a convergent synthesis of the antiretroviral medicine maraviroc. Mechanistic studies demonstrate that a residual 0.5 equivalents of carboxylic acid from the amidation step is responsible for the generation of silane reductants with augmented reactivity, which allow secondary amides, previously unreactive in zinc/phenylsilane systems, to be reduced.

Palladium-Catalyzed Benzylic C-H Arylation of Azaarylmethylamines

A direct C-H functionalization approach to produce aryl(azaaryl)methylamines from azaarylmethylamines without directing groups is described. Under conditions where the azaarylmethylamines' C-H is reversibly deprotonated, a Pd(OAc)2/NIXANTPHOS-b

Anti-asthmatic, anti-allergic, anti-cholinergic, bronchodilator and anti-inflammatory 1-[(benzoylphenyl)-lower-alkyl]piperidines and analogs thereof

1-[(3- or 4-Benzoylphenyl)-lower-alkyl]-[(CH2)n --N=B]-substituted-piperidines, useful as anti-asthmatic, anti-allergic, anti-cholinergic, bronchodilator and anti-inflammatory agents, are prepared by alkylation of an appropriate subs