5784-78-1Relevant academic research and scientific papers
Photocatalysis method for preparing polysubstituted quinoxaline in water-containing medium
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Paragraph 0018-0039, (2021/05/08)
The invention provides a photocatalysis method for preparing polysubstituted quinoxaline in a water-containing medium, and belongs to the technical field of organic synthesis. The method comprises the following steps: by taking R1-substituted quinoxaline and R2-substituted benzoylformic acid as raw materials, putting a photocatalyst, an oxidant, an additive and a water-containing solvent into a reaction tube, and irradiating for 12 hours at room temperature under a blue light illumination condition, thereby obtaining the product polysubstituted quinoxaline derivative. The iridium complex is adopted as a photosensitive catalyst, decarboxylation acylation reaction is directly carried out in a water-containing medium, the method has the advantages of being mild in reaction condition, high in yield and the like, and new method guidance is provided for preparation of the compound.
Discovery of 3-arylquinoxaline derivatives as potential anti-dengue virus agents
Tseng, Chih-Hua,Han, Cheng-Ruei,Tang, Kai-Wei
, (2019/10/28)
We designed and synthesized a series of novel 3-arylquinoxaline derivatives and evaluated their biological activities as potential dengue virus (DENV) replication inhibitors. Among them, [3-(4-methoxyphenyl)quinoxalin-2-yl](phenyl)methanol (19a), [6,7-dic
PIDA-mediated intramolecular oxidative C-N bond formation for the direct synthesis of quinoxalines from enaminones
Zhang, Hong,Shen, Jinhai,Yang, Zhenhui,Cui, Xiuling
, p. 7718 - 7722 (2019/03/20)
A intramolecular oxidative C(sp2)-N bond formation mediated by hypervalent iodine(iii) to obtain quinoxalines from readily available N-(2-acetaminophenyl)enaminones was developed. A tandem process involving PIDA-mediated intramolecular condensation cyclization and a subsequent elimination was postulated, which was highly efficient and metal-free under mild conditions. Moreover, flexible structural modifications of quinoxalines bearing carbonyl groups are of interest for further transformations as building blocks in organic synthesis.
Iron-Catalyzed Annulation of 1,2-Diamines and Diazodicarbonyls for Diverse and Polyfunctionalized Quinoxalines, Pyrazines, and Benzoquinoxalines in Water
Pandit, Rameshwar Prasad,Kim, Sung Hong,Lee, Yong Rok
, p. 3586 - 3599 (2016/11/25)
A novel and facile iron-catalyzed tandem annulation of o-phenylenediamines and diazocarbonyls in water for the construction of polyfunctionalized quinoxalines has been developed. The key strategy includes the one-pot domino N?H insertion, cyclization, and
Synthesis of Quinoxaline Derivatives via Tandem Oxidative Azidation/Cyclization Reaction of N -Arylenamines
Ma, Haichao,Li, Dianjun,Yu, Wei
, p. 868 - 871 (2016/03/04)
A new method was developed for the synthesis of quinoxalines. This method employs N-arylenamines and TMSN3 as the starting materials and implements two oxidative C-N bond-forming processes in a tandem pattern by using (diacetoxyiodo)benzene as the common oxidant. The present reaction conditions are mild and simple and thus are useful in practical synthesis. (Chemical Equation Presented).
Quinoxaline synthesis in novel tandem one-pot protocol
Anil Kumar,Madhav,Harsha Vardhan Reddy,Nageswar
supporting information; experimental part, p. 2862 - 2865 (2011/06/21)
A variety of quinoxalines were synthesized via tandem one-pot procedure for the first time in water medium. The key strategy was the in situ preparation of α-halo-β-keto esters by the reaction of N-bromo succinimide with β-keto esters and further condensa
Synthesis of 2-aroylquinoxalines, 1-aroylphthalazines, and 4-aroylcinnolines; an aroylation method using arenecarbaldehydes catalyzed by azolium salt1
Miyashita, Akira,Suzuki, Yumiko,Iwamoto, Ken-Ichi,Oishi, Etsuo,Higashino, Takeo
, p. 405 - 413 (2007/10/03)
2-Aroylquinoxalines (5,6), 1-aroylphthalazines (10,11), and 4-aroylcinnolines (13) were synthesized by using arenecarbaldehydes (2) in the presence of an azolium salt (1) in moderate to good yields. 1,3-Dimethylimidazolium iodide (1a) and sodium sulfinate
