7295-52-5

Basic information

• Product Name: 1-Octanone, 1-(4-chlorophenyl)-
• CAS NO: 7295-52-5
• Molecular Formula: C14H19ClO
• Molecular Weight: 238.757
• Mol File: 7295-52-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-Octanone, 1-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Octanone, 1-(4-chlorophenyl)-(7295-52-5)
• EPA Substance Registry System: 1-Octanone, 1-(4-chlorophenyl)-(7295-52-5)

Safety Data

• Hazardous Substances Data: 7295-52-5(Hazardous Substances Data)

Usage

Type of compound

man-made chemical compound

Common uses

production of perfumes and flavorings, manufacturing of scented products, chemical and pharmaceutical industries

Classification

aromatic ketone

Scent

faint, sweet, and floral (similar to flowers and fruit)

Potential hazards

harmful if inhaled or ingested, should be handled with caution in a controlled environment

Upstream product

• 108-90-7 chlorobenzene 
• 111-64-8 n-octanoic acid chloride 
• 190065-72-6 1-chloro-4-(oct-1-yn-1-yl)benzene 
• 4282-40-0 1-Iodoheptane 
• 1679-18-1 4-Chlorophenylboronic acid 
• 13939-06-5 molybdenum hexacarbonyl 
• 3391-10-4 1-(p-chlorophenyl)ethyl alcohol 
• 111-27-3 hexan-1-ol 
• 592-41-6 1-hexene 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 106-39-8 bromochlorobenzene 
• 124-13-0 Octanal 
• 623-03-0 4-Cyanochlorobenzene 
• 13125-66-1 n-heptylmagnesium bromide 

Downstream Products

• 63884-78-6 4'-aminooctanoylphenone 
• 16245-79-7 4-octylaniline 
• 92318-17-7 1.1-Dichlor-1-<4-chlor-phenyl>-octan 

Relevant articles and documents

Ring size and nothing else matters: unusual regioselectivity of alkyne hydration by NHC gold(i) complexes

We have investigated the role of ring sizes and substituents in NHC ligands in some (NHC)Au(i) complexes in the hydration of internal alkynes. Despite the fact that using (NHC)Au(i) complexes in the hydration of diarylacetylenes leads to Markovnikov-type products, the precise tuning of ligands allows changing the regioselectivity in arylalkylacetylene hydration to the anti-Markovnikov-type.

Palladium and visible-light mediated carbonylative Suzuki-Miyaura coupling of unactivated alkyl halides and aryl boronic acids

Herein, a simple and efficient method for the palladium-catalyzed carbonylation of aryl boronic acids with unactivated alkyl iodides and bromides under visible-light irradiation, ambient temperature and low CO-pressure is presented. Notably, the procedure uses readily available equipment and an inexpensive palladium catalyst to generate the key alkyl radical intermediate. These mild conditions enabled the synthesis of a range of functionalized aryl alkyl ketones including the antipsychotic drug, melperone.

Reductive bromine atom-transfer reaction

Atom-transfer radical (ATR) reactions of alkenes with R-X usually give products having new C-C and C-X bonds at the adjacent carbons. However, when the reaction was carried out under irradiation using a low-pressure Hg lamp, addition/reduction products were obtained in good yield. Hydrogen bromide, formed by H-abstraction of a bromine radical from alkenes, is likely to play a key role in the reductive ATR reaction.