73-63-2

Basic information

• Product Name: 3-(1-Piperidinyl)propiophenone HCl
• Synonyms: 3-(1-Piperidinyl)propiophenone HCl;1-phenyl-3-(piperidin-1-yl)propan-1-one;3-(1-Piperidinyl)propiophenone;(2-(1-PIPERIDINYL)ETHYL)PHENYL KETONE;(2-(-Piperidinyl)ethyl)phenyl ketone;β-Piperidinopropiophenone;3-(1-PIPERIDINYL)PROPIOPHENONE 98%;1-Phenyl-3-piperidino-1-propanone
• CAS NO: 73-63-2
• Molecular Formula: C₁₄H₁₉NO
• Molecular Weight: 253.7677
• Mol File: 73-63-2.mol
• Article Data: 20

Chemical Properties

• Melting Point: 192-193 °C
• Boiling Point: 345.4 °C at 760 mmHg
• Flash Point: 127.1 °C
• Appearance: /
• Density: 1.029 g/cm³
• PKA: 8.78±0.10(Predicted)
• CAS DataBase Reference: 3-(1-Piperidinyl)propiophenone HCl(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-Piperidinyl)propiophenone HCl(73-63-2)
• EPA Substance Registry System: 3-(1-Piperidinyl)propiophenone HCl(73-63-2)

Safety Data

• Hazardous Substances Data: 73-63-2(Hazardous Substances Data)

Usage

Uses

3-Piperidinopropiophenone is used in the synthesis of semicarbazones of acetophenone which possesses anti-convulsant activity. Also, it is an intermediate used in the synthesis of Cycrimine Hydrochloride (C991450), which is a cholinolytic anti-Parkinson drug which can cause neuromuscular blockades in isolated rat diaphragms.

Upstream product

• 110-89-4 piperidine 
• 50-00-0 formaldehyd 
• 614-20-0 3-oxo-3-phenylpropionic acid 
• 29636-75-7 3-bromo-1-phenylpropan-1-one 
• 6091-44-7 piperidine hydrochloride 
• 98-86-2 acetophenone 
• 75-09-2 dichloromethane 
• 776-75-0 N-benzoylpiperidine 
• 1826-67-1 vinyl magnesium bromide 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 100-52-7 benzaldehyde 
• 14103-77-6 1,3-dimethylimidazolidine 
• 17206-00-7 N-methylpiperidine-N-oxide 
• 936-59-4 3-chloropropiophenone 

Downstream Products

• 102008-18-4 2-(1-phenyl-3-piperidino-propyl)-pyridine 
• 3506-37-4 (E)-1-phenyl-3-(piperidin-1-yl)prop-2-en-1-one 
• 95294-69-2 2-phenyloctahydropyrido[2,1-b][1,3]oxazine 
• 140697-48-9 1-Aza-7-methyl-7-phenylbicyclo<4.3.0>nonane 
• 109933-22-4 1-(3-phenylbut-3-en-1-yl)piperidine 
• 952-51-2 1-phenyl-3-(piperidin-1-yl)propan-1-ol 
• 41797-27-7 (R)-1-Phenyl-3-piperidin-1-yl-propan-1-ol 
• 41797-26-6 (S)-3-N-Piperidinyl-1-phenyl-1-propanol 
• 5724-13-0 Methyl-<3-oxo-3-phenyl-propyl>-piperidinium-jodid 
• 94124-54-6 1,1-dimethoxy-1-phenyl-3-(1'-piperidinyl)propan-2-ol 
• 130820-13-2 1-(4-cyclopropylphenyl)-1-phenyl-3-(1-piperidinyl)propanol 
• 103156-72-5 3-(3r-benzoyl-4c-hydroxy-4t-phenyl-piperidino)-1-phenyl-propan-1-one 
• 42575-08-6 3-(3-phenyl-2-pyrazolin-1-yl)propiophenone 
• 111475-19-5 3-phenyl-1-piperidin-1-yl-hex-5-en-3-ol 

Relevant articles and documents

Metal-free synthesis of β-aminoketones by the reductive hydroamination of ynones

This study describes a cascade method for the synthesis of β-aminoketones through the reductive hydroamination of alkynes under very mild metal-free conditions. It allows for the rapid conversion of ynones and amines into corresponding β-aminoketones with a broad substrate scope and diverse functionalities. This straightforward and easy-to-handle reaction process can be successfully applied for the synthesis of Proroxan and Propipocaine, offering a potential option for the synthesis of drug molecules with the β-aminoketone skeleton.

Evaluation of Cytotoxic Properties of N,N'-bis[(1-aryl-3-heteroaryl)propylidene]-hydrazine dihydrochlorides

N,N'-bis[(1-aryl-3-heteroaryl)propylidene]hydrazine dihydrochlorides, P1, P4 – P8, and R1 – R7, were assayed against human oral squamous cell carcinoma (HSC-2, HSC-3, HSC-4), human promyelocytic leukemia cell line (HL-60), and human normal oral cells (HGF

PEG 400/cerium ammonium nitrate combined with microwave-assisted synthesis for rapid access to beta-amino ketones. an easy-to-use protocol for discovering new hit compounds

Compound libraries are important requirement in target-based drug discovery. In the present work, a small focused compound library based on β-aminoketone scaffold has been prepared combining microwave-assisted organic synthesis (MAOS) with polymer-assiste