3-Piperidinopropiophenone

Base Information

Chemical Name:3-Piperidinopropiophenone
CAS No.:73-63-2
Molecular Formula:C14H19NO
Molecular Weight:217.311
Hs Code.:2933399090
European Community (EC) Number:635-445-5
NSC Number:5755
UNII:XFA6RU9GWY
DSSTox Substance ID:DTXSID60223273
Nikkaji Number:J29.198F
Wikidata:Q27293820
ChEMBL ID:CHEMBL1616357
Mol file:73-63-2.mol

Synonyms:73-63-2;3-Piperidinopropiophenone;1-phenyl-3-(piperidin-1-yl)propan-1-one;1-phenyl-3-piperidin-1-ylpropan-1-one;beta-Piperidinopropiophenone;Piperidine, 1-(2-benzoylethyl)-;1-Propanone, 1-phenyl-3-(1-piperidinyl)-;Propiophenone, 3-piperidino-;.beta.-Piperidinopropiophenone;N-(.beta.-Benzoylethyl)piperidine;UNII-XFA6RU9GWY;XFA6RU9GWY;NSC 5755;N-(beta-Benzoylethyl)piperidine;NA 65;NSC-5755;1-phenyl-3-(1-piperidyl)propan-1-one;3-Piperidinopropiophenon;1-Phenyl-3-piperidin-1-yl-propan-1-one;CBMicro_016794;Oprea1_473994;Oprea1_876854;beta-1-Piperidylpropiophenone;SCHEMBL5356971;CHEMBL1616357;DTXSID60223273;NSC5755;HMS1680G22;NA-65;STK700138;AKOS000666665;1-Phenyl-3-(1-piperidinyl)-1-propanone;3-PIPERIDINO-1-PHENYLPROPAN-1-ONE;1-Propanone, 1-phenyl-3-(1-piperidyl)-;1-Phenyl-3-(1-piperidinyl)-1-propanone #;FT-0646512;A26897;EN300-221857;A837881;1-Propanone, 1-phenyl-3-(1-piperidinyl)- (9CI);Q27293820;TRIHEXYPHENIDYL HYDROCHLORIDE IMPURITY A [EP IMPURITY]

Suppliers and Price of 3-Piperidinopropiophenone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-Piperidinopropiophenone
100mg
$ 95.00

Sigma-Aldrich
Trihexyphenidyl impurity A European Pharmacopoeia (EP) Reference Standard
y0000068
$ 190.00

American Custom Chemicals Corporation
1-PHENYL-3-(PIPERIDIN-1-YL)PROPAN-1-ONE 95.00%
5MG
$ 496.32

Total 35 raw suppliers

Chemical Property of 3-Piperidinopropiophenone

Chemical Property:

Melting Point:192-193 °C
Boiling Point:345.4 °C at 760 mmHg
PKA:8.78±0.10(Predicted)
Flash Point:127.1 °C
PSA：20.31000
Density:1.029 g/cm³
LogP:2.68320
XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:217.146664230
Heavy Atom Count:16
Complexity:215

Purity/Quality:

99.9% ^*data from raw suppliers

3-Piperidinopropiophenone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(CC1)CCC(=O)C2=CC=CC=C2
Uses 3-Piperidinopropiophenone is used in the synthesis of semicarbazones of acetophenone which possesses anti-convulsant activity. Also, it is an intermediate used in the synthesis of Cycrimine Hydrochloride (C991450), which is a cholinolytic anti-Parkinson drug which can cause neuromuscular blockades in isolated rat diaphragms.

Technology Process of 3-Piperidinopropiophenone

There total 22 articles about 3-Piperidinopropiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 110-89-4
piperidine

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 98-86-2
acetophenone

: 73-63-2
1-phenyl-3-(piperidin-1-yl)propan-1-one

Guidance literature:: With C₇H₁₃N₂O₃S⁽¹⁺⁾*C₁₀H₁₅O₄S^(1-); at 25 ℃; for 0.5h;
DOI:10.1016/j.molliq.2020.114370

Reference yield: 95.0%

: 110-91-8,99108-56-2
morpholine

: 6919-61-5
N-methoxy-N-methylbenzamide

: 1826-67-1
vinyl magnesium bromide

: 73-63-2
1-phenyl-3-(piperidin-1-yl)propan-1-one

Guidance literature:: N-methoxy-N-methylbenzamide; vinyl magnesium bromide; In tetrahydrofuran; at 0 - 20 ℃; for 1.16667h;

morpholine; In tetrahydrofuran; water; at 20 ℃; for 0.333333h; Further stages.;
DOI:10.1021/jo0057497