High yield protection of purine ribonucleosides for H-phosphonate RNA synthesis

DOI: 10.1016/S0040-4039(97)01767-X

Source and publish data:

Tetrahedron Letters p. 7135 - 7138 (1997)

Update date:2022-08-16

Topics:

Authors:

Zhang, Xiaohu

Abad, Jose-Luis

Huang, Qingtao

Zeng, Fan

Gaffney, Barbara L.

Jones, Roger A.

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Article abstract of DOI:10.1016/S0040-4039(97)01767-X

We report a new method for protecting nucleosides for hydrogen phosphonate RNA synthesis that gives very high yields for the purines. This method is based on our finding that, for adenosine and guanosine, silylation of a mixture of 2' and 3'H-phosphonates in the presence of DBU is highly selective for the 2' hydroxyl.

Full text of DOI:10.1016/S0040-4039(97)01767-X

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