7388-44-5

Usage

Uses

Used in Medicinal Chemistry and Pharmaceutical Research:
Tetrahydro-3,5-bis(methoxymethyl)-4H-1,3,5-oxadiazin-4-one serves as a valuable compound in medicinal chemistry and pharmaceutical research due to its potential biological activity, which makes it a candidate for the development of new drugs and therapeutic agents.
Used as a Precursor in Pharmaceutical and Agrochemical Synthesis:
In the synthesis of various pharmaceuticals and agrochemicals, tetrahydro-3,5-bis(methoxymethyl)-4H-1,3,5-oxadiazin-4-one is used as a precursor. Its unique structure allows it to be a key component in the creation of a range of different chemical products.
Used in Material Development:
tetrahydro-3,5-bis(methoxymethyl)-4H-1,3,5-oxadiazin-4-one has been studied for its potential as a building block in the development of new materials. Its properties and reactivity make it a promising candidate for use in the creation of innovative materials with specific applications.
Used as a Synthetic Intermediate in Organic Chemistry:
Tetrahydro-3,5-bis(methoxymethyl)-4H-1,3,5-oxadiazin-4-one also functions as a synthetic intermediate in organic chemistry. Its ability to participate in various chemical reactions makes it useful in the synthesis of complex organic compounds for a wide range of applications.

InChI:InChI=1/C7H14N2O4/c1-11-3-8-5-13-6-9(4-12-2)7(8)10/h3-6H2,1-2H3

Upstream product

• 50-00-0 formaldehyd 
• 57-13-6 urea 
• 67-56-1 methanol 
• 2787-01-1 tetra(hydroxymethyl)urea 
• 1910-86-7 bis-(N'-hydroxymethyl-ureidomethyl)-ether 

Downstream Products

• 22939-30-6 3-hydroxymethyl-1,3,5-oxadiazinan-4-on 
• 542-29-0 1,3,5-oxadiazinan-4-on 
• 7327-69-7 3,5-bis-hydroxymethyl-1,3,5-oxadiazinan-4-on 
• 102894-37-1 3,5-bis-(2-ethoxy-3,5-dimethyl-benzyl)-tetrahydro-[1,3,5]oxadiazin-4-one 
• 36042-69-0 hexa-P-phenyl-P,P'-(4-oxo-[1,3,5]oxadiazinane-3,5-diyldimethyl)-bis-phosphonium; dibromide 
• 102471-03-4 3,5-bis-(2-hydroxy-3,5-dimethyl-benzyl)-tetrahydro-[1,3,5]oxadiazin-4-one 

Relevant academic research and scientific papers

Quantitative and qualitative 1H, 13C, and 15N NMR spectroscopic investigation of the urea-formaldehyde resin synthesis

Urea-formaldehyde resins are bulk products of the chemical industry. Their synthesis involves a complex reaction network. The present work contributes to its elucidation by presenting results from detailed NMR spectroscopic studies with different methods. Besides1H NMR and13C NMR, 15N NMR spectroscopy is also applied.15N-enriched urea was used for the investigations. A detailed NMR signal assignment and a model of the reaction network of the hydroxymethylation step of the synthesis are presented. Because of its higher spectral dispersion and the fact that all key reactions directly involve the nitrogen centers,15N NMR provides a much larger amount of detail than do1H and13C NMR spectroscopy. Symmetric and asymmetric dimethylol urea can be clearly distinguished and separated from monomethylol urea, trimethylol urea, and methylene-bridged urea. The existence of hemiformals of methylol urea is confirmed. 1,3,5-Oxadiazinan-4-on (uron) and its derivatives were not found in the reaction mixtures investigated here but were prepared via alternative routes. The molar ratios of formaldehyde to urea were 1, 2, and 4, the pH values 7.5 and 8.5, and the reaction temperature 60 °C. Copyright 2014 John Wiley & Sons, Ltd. 15N-enriched urea is used in combination with quantitative15N and13C NMR spectroscopy and a Virtual Reference. This allows for a detailed peak assignment and absolute quantification of the early steps of this industrial process, which involves a complex reaction network. A detailed peak assignment for all three nuclei, a full quantitative description of the reaction mixture's composition and a model describing changes in shift depending on formaldehyde substitution are given. Copyright

The Formation Pathway of 3,5-Bis(methoxymethyl)perhydro-1,3,5-oxadiazin-4-one

The investigation of the reactions of urea and its methyl derivatives with formaldehyde elucidated the formation pathway of 3,5-bis(methoxymethyl)perhydro-1,3,5-oxadiazin-4-one. 1) The addition of formaldehyde to urea became increasingly difficult according to the increase of the number of added formaldehyde molecules, probably because of the steric hindrance of the hydroxymethyl groups. 2) 3,5-Bis(methoxymethyl)perhydro-1,3,5-oxadiazin-4-one was concluded to be derived from urea via tris(hydroxymethyl)urea and 3-(hydroxymethyl)perhydro-1,3,5-oxadiazin-4-one but not via tetrakis(hydroxymethyl)urea or perhydro-1,3,5-oxadiazin-4-one.