7399-68-0

Basic information

• Product Name: 2-(4-chlorophenyl)-4,5-dihydro-1,3-oxazole
• Synonyms: 2-(4-Chlorophenyl)-4,5-dihydro-1,3-oxazole; oxazole, 2-(4-chlorophenyl)-4,5-dihydro-
• CAS NO: 7399-68-0
• Molecular Formula: C₉H₈ClNO
• Molecular Weight: 181.6189
• Mol File: 7399-68-0.mol
• Article Data: 37

Chemical Properties

• Boiling Point: 283.8°C at 760 mmHg
• Flash Point: 125.5°C
• Density: 1.28g/cm³
• Vapor Pressure: 0.00529mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: 2-(4-chlorophenyl)-4,5-dihydro-1,3-oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-4,5-dihydro-1,3-oxazole(7399-68-0)
• EPA Substance Registry System: 2-(4-chlorophenyl)-4,5-dihydro-1,3-oxazole(7399-68-0)

Safety Data

• Hazardous Substances Data: 7399-68-0(Hazardous Substances Data)

Usage

Chemical Family

2-(4-chlorophenyl)-4,5-dihydro-1,3-oxazole belongs to the oxazole family of chemical compounds.

Usage in Organic Synthesis and Pharmaceutical Research

The compound is used in organic synthesis and pharmaceutical research due to its various biological activities.

Antimicrobial and Anti-inflammatory Properties

2-(4-chlorophenyl)-4,5-dihydro-1,3-oxazole has antimicrobial and anti-inflammatory properties, making it a potential candidate for the development of new drugs.

Potential Role in the Treatment of Certain Diseases and Conditions

The compound has been studied for its potential role in the treatment of certain diseases and conditions, making it an important chemical for further research and development.

Upstream product

• 19117-21-6 1-(4-chlorobenzoyl)aziridine 
• 141-43-5 ethanolamine 
• 74-11-3 para-chlorobenzoic acid 
• 623-03-0 4-Cyanochlorobenzene 
• 5714-33-0 2-(2-mercaptoethyl)-aminoethanol 
• 104-88-1 4-chlorobenzaldehyde 
• 36615-72-2 phenacylsulfonylacetic acid methyl ester 
• 1943-83-5 2-chloroethyl isothiocyanate 
• 122-01-0 4-chloro-benzoyl chloride 
• 106-39-8 bromochlorobenzene 
• 201230-82-2 carbon monoxide 
• 870-24-6 2-chloroethanamine hydrochloride 
• 52636-85-8 2-(4-chloro-phenyl)-oxazolidine 
• 67-64-1 acetone 

Downstream Products

• 80253-66-3 cyanomethyl 4-chlorobenzoate 
• 1119512-94-5 bis-(2-[p-chlorophenyl]-2-oxazoline-κ1N) zinc(II) chloride 
• 1119513-01-7 bis-(2-[p-chlorophenyl]-2-oxazoline-κ1N) zinc(II) bromide 
• 82891-93-8 2-(2-methyl-4-n-propylphenyl)-2-oxazoline 
• 82891-91-6 2-(2-methyl-4-chlorophenyl)-2-oxazoline 
• 126773-87-3 C₉H₅⁽²⁾HClNO 
• 104-88-1 4-chlorobenzaldehyde 
• 46047-24-9 2-(4-chlorophenyl)oxazole 
• 126773-84-0 5-Bromo-2-(4-chlorophenyl)oxazole 
• 82891-84-7 2-(4-propylphenyl)-4,5-dihydrooxazole 
• 82891-89-2 2-<2-(methylthio)-4-chlorophenyl>-2-oxazoline 

Relevant articles and documents

Facile one-pot synthesis of 2-oxazoline

We developed a facile one-pot synthesis of 2-oxazolines from carboxylic acid and 2-chloroethyl isocyanate, involving amide bond formation and a following intramolecular cyclization using 4-dimethylaminopyridine as the catalyst. A large variety of functional groups are well tolerated by the mild reaction conditions to afford diverse 2-oxazolines in good to excellent yields. This reaction will keep the chirality of the isocyanate at position 1, the R2 substituted carbon. Microwave-assisted synthesis can further enhance the reaction yield and reduce the reaction time to 5 min. This method facilities the synthesis of 2-oxazolines for diverse applications, such as 2-oxazoline derived polymers and materials.

Mild, Selective Ru-Catalyzed Deuteration Using D2O as a Deuterium Source

A method for the selective deuteration of polyfunctional organic molecules using catalytic amounts of [RuCl2(PPh3)3] and D2O as a deuterium source is presented. Through variation of additives like CuI, KOH, and various amounts of zinc powder, orthogonal chemoselectivities in the deuteration process are observed. Mechanistic investigation indicates the presence of different, defined Ru-complexes under the given specific conditions.

A 2 - substituted oxazoline or 2 - substituted piperazine synthetic method (by machine translation)

The invention discloses a method for synthesizing 2 - substituted oxazoline or 2 - substituted oxazine new method, by nitrile and amino ethanol or 3 - amino - 1 - propanol as raw material, in the absence of solvent, can be used for the recycling of the sulfur to induce synthesis of 2 - substituted oxazoline and 2 - substituted piperazine. The method of the invention has low cost, simple reaction process, mild reaction conditions, the reaction time is short, the yield and the like, is suitable for the industrial generation. (by machine translation)