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Transformation of Acyclic Ketones into Aldehydes and Ketones with Substituted Side Chains
Tietze, Lutz-F.,Kinast, Guenther
, p. 451 - 460 (2007/10/02)
Aminomethylation of the acyclic ketones 1/2 leads to the aminoketones 3/4 which give, after reduction, quaternisation and ion exchange or previous reaction with a Grignard reagent, the hydroxyammonium compounds 9/10 and 14, respectively.Flash thermolysis of 9/10 yields the aldehydes 7 and of 14 the ketone 15 in which one side-chain of the educt 2b is substituted by the alkyl group of the Grignard reagent.
