74364-75-3

Upstream product

• 10606-72-1 (R)-mandelic acid ethyl ester 
• 75-36-5 acetyl chloride 
• 74327-04-1 ethyl 2-acetoxy-2-phenylacetate 
• 108-05-4 vinyl acetate 
• 774-40-3 hydroxy-phenyl-acetic acid ethyl ester 
• 611-71-2 MANDELIC ACID 
• 100-52-7 benzaldehyde 
• 532-28-5 (RS)-mandelonitrile 
• 123-20-6 vinyl n-butyrate 
• 51019-43-3 (R)-(-)-O-acetylmandelic acid 
• 541-41-3 chloroformic acid ethyl ester 
• 64-17-5 ethanol 
• 127-08-2 potassium acetate 

Downstream Products

• 611-71-2 (R)-Mandelic Acid 
• 791074-29-8 (R,R)-O-acetylmandelic acid (2-hydroxymethyl-1-phenyl)ethylamide 
• 791074-35-6 (R)-(phenyl)[(4R)-4-phenyl-4,5-dihydrooxazol-2-yl]methyl acetate 
• 928013-77-8 (R)-[(4S)-4-isopropyl-4,5-dihydrooxazol-2-yl](phenyl)methyl acetate 

Relevant academic research and scientific papers

Kinetic resolution of mandelate esters via stereoselective acylation catalyzed by lipase PS-30

By using lipase PS-30 as catalyst, the kinetic resolution of a series of racemic mandelate esters has been achieved via stereoselective acylation. The value of kinetic enantiomeric ratio (E) reached up to 197.5. Substituent effect is briefly discussed.

Convenient synthesis of a new class of chiral hydroxymethyl-dihydrooxazole ligands and their application in asymmetric addition of diethylzinc to aromatic aldehydes

A number of chiral hydroxymethyl-substituted dihydrooxazoles were synthesized from D- or L-mandelic acid and amino alcohols. The chiral ligands thus obtained were tested as catalyst in the asymmetric addition of diethylzinc to aromatic aldehydes, and the

N-acylpyridinium trifluoromethanesulfonates and tetrafluoroborates: Shuttle reagents for the acylation of enantiopure secondary alcohols

Several enanflopure alcohols are esterified with N-acyl-4- benzylpyfidinium trifluoromethanesulfonates 7b,d,f or tetrafluoroborates 7a,c,e. These reagents, which can be generated in situ, or isolated as stable salts, are synthesized from readily available 4-alkylpyridines 3, acyl chlorides 4 and strong protic acids 6. The acyl moiety is transferred under neutral conditions and in high yields. The heterocyclic component 3a can be re-isolated almost quantitatively. The acetate, benzoate and pivaloate groups were selected with regard to their application as frequently used protecting groups for hydroxy compounds. As shown by paramagnetic shift experiments with a chiral europium(III) complex, these acylations proceed without detectable racemization or epimerization.

Tritiated chiral alkanes as substrates for soluble methane monooxygenase from Methylococcus capsulatus (Bath): Probes for the mechanism of hydroxylation

The tritiated chiral alkanes (S)-[1-2H1, 1-3H]ethane, (R)-[1-2H1, 1-3H]ethane, (S)-[1-2H1, 1-3H]butane, (R)[1-2H1, 1-3H]but

Synthesis of optically active alkynyl alcohols and α-hydroxy esters by microbial asymmetric hydrolysis of the corresponding acetates

Asymmetric hydrolysis of the acetates of racemic alkynyl alcohols and α-hydroxy esters by Bacillus subtilis var. Niger afforded optically active acetates and alcohols in 7-90% optical purities. The both enantiomers of optically pure mandelie acid were prepared by this microbial method.