745076-37-3

Upstream product

• 108-24-7 acetic anhydride 
• 132201-33-3 (2R,3S)-N-benzoyl-3-phenylisoserine 
• 98-88-4 benzoyl chloride 
• 622851-14-3 (2S,3S)-2-(3-furyl)-3-phenyl-1-benzoylaziridine 
• 622851-08-5 (4S,5S)-1,4-diphenyl-5-(3-furyl)-4,5-dihydro-oxazole 
• 622851-11-0 (2S,3S)-2-(3-furyl)-3-phenylaziridine 
• 55-21-0 benzamide 
• 10387-93-6 N-(methoxy(phenyl)methyl)benzamide 
• 701305-71-7 Acetic acid (1R,2S)-2-amino-1-hydroxymethyl-2-phenyl-ethyl ester 
• 680982-37-0 (2R,3S)-2-Acetoxy-3-amino-3-phenyl-propionic acid 
• 622851-09-6 (1S,2S)-[2-phenyl-2-benzylamino-1-(3-furyl)-ethyl]acetate 
• 622851-12-1 (1S,2S)-N-[1-phenyl-2-hydroxy-2-(3-furyl)-ethyl]benzamide 
• 51608-62-9 (E)-N-benzylidenebenzamide 
• 100-52-7 benzaldehyde 

Downstream Products

• 146848-86-4 methyl (2R,3S)-2-acetoxy-3-phenyl-3-benzoylaminopropanoate 
• 132201-33-3 (2R,3S)-N-benzoyl-3-phenylisoserine 
• 1435474-96-6 (2R,3S)-[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] 2-acetoxy-3-benzamido-3-phenylpropanoate 
• 1435474-97-7 (2R,3S)-[2-(7-chloroquinolin-4-ylamino)ethyl] 2-acetoxy-3-benzamido-3-phenylpropanoate 
• 1435474-99-9 (2R,3S)-[3-(7-chloroquinolin-4-ylamino)propyl] 2-acetoxy-3-benzamido-3-phenylpropanoate 
• 32981-85-4 methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate 

Relevant academic research and scientific papers

Design, synthesis, and antiplasmodial activity of hybrid compounds based on (2 R,3 S)- N-benzoyl-3-phenylisoserine

A series of hybrid compounds based on (2R,3S)-N-benzoyl-3-phenylisoserine, artemisinin, and quinoline moieties was synthesized and tested for in vitro antiplasmodial activity against erythrocytic stages of K1 and W2 strains of Plasmodium falciparum. Two hybrid compounds incorporating (2R,3S)-N-benzoyl-3- phenylisoserine and artemisinin scaffolds were 3- to 4-fold more active than dihydroartemisinin, with nanomolar IC50 values against Plasmodium falciparum K1 strain.

A highly efficient synthesis of the C-13 side-chain of taxol using Shibasaki's asymmetric Henry reaction

The synthesis of the C-13 side-chain of taxol has been achieved using Shibasaki's asymmetric Henry reaction catalyzed by an optically active rare earth lanthanum-(R)-binaphthol complex.

NOVEL TAXANES AND METHODS RELATED TO USE AND PREPARATION THEREOF

Disclosed are taxanes having utility as intermediates in the preparation of paclitaxel, taxotere and analogs thereof, and methods related to the preparation of the same.

Asymmetric Sulfur Ylide Mediated Aziridination: Application in the Synthesis of the Side Chain of Taxol

(Formula presented). Sulfur ylide methodology has been used to construct the Taxol side chain with a high degree of enantioselectivity via a trans-aziridine followed by stereospecific rearrangement of the trans-benzoylaziridine into a trans-oxazoline.