745825-75-6

Basic information

• Product Name: 1-(2-((4-Methoxyphenyl)ethynyl)phenyl)ethanone
• Synonyms: 1-(2-((4-Methoxyphenyl)ethynyl)phenyl)ethanone
• CAS NO: 745825-75-6
• Molecular Formula: C₁₇H₁₄O₂
• Molecular Weight: 250.29186
• EINECS: -0
• Mol File: 745825-75-6.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-((4-Methoxyphenyl)ethynyl)phenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-((4-Methoxyphenyl)ethynyl)phenyl)ethanone(745825-75-6)
• EPA Substance Registry System: 1-(2-((4-Methoxyphenyl)ethynyl)phenyl)ethanone(745825-75-6)

Safety Data

• Hazardous Substances Data: 745825-75-6(Hazardous Substances Data)

Usage

General Description

1-(2-((4-Methoxyphenyl)ethynyl)phenyl)ethanone is a chemical compound that belongs to the class of ketones. It has the molecular formula C17H14O2 and a molecular weight of 250.29 g/mol. 1-(2-((4-Methoxyphenyl)ethynyl)phenyl)ethanone is a derivative of acetophenone, where one of the phenyl groups is substituted with a 4-methoxyphenyl group and an ethynyl moiety. It is a pale yellow solid that is sparingly soluble in water and more soluble in organic solvents. 1-(2-((4-Methoxyphenyl)ethynyl)phenyl)ethanone has been the subject of research for its potential applications in the pharmaceutical and materials science fields.

Upstream product

• 1441-97-0 2'-(methylthio)acetophenone 
• 768-60-5 4-methoxyphenylacetylen 
• 6630-33-7 ortho-bromobenzaldehyde 
• 77123-58-1 2-[2-(trimethylsilyl)ethynyl]benzaldehyde 
• 166757-14-8 2-(1-Hydroxyethyl)-1-<2-(trimethylsilyl)ethynyl>benzene 
• 88-65-3 2-bromobenzoic-acid 
• 7154-66-7 2-bromobenzoic acid chloride 
• 899425-05-9 2-bromo-N-methoxy-N-methylbenzamide 
• 696-62-8 para-iodoanisole 
• 104190-22-9 1-(2-ethynylphenyl)ethan-1-one 
• 98-86-2 acetophenone 
• 2142-70-3 2-iodoacetophenone 
• 2142-69-0 2-bromophenyl methyl ketone 

Downstream Products

• 1284293-85-1 C₁₇H₁₄O₂ 
• 100-09-4 4-methoxybenzoic acid 
• 218-01-9 chrysene 
• 1394123-35-3 1-(2-((4-methoxyphenyl)ethynyl)phenyl)-3-(p-tolyl)prop-2-en-1-one 
• 6072-52-2 1,3-bis(4-methoxyphenyl)-8H-indeno[1,2-c]thiophen-8-one 

Relevant articles and documents

Au(I)-Catalyzed 6-endo-dig Cyclizations of Aromatic 1,5-Enynes to 2-(Naphthalen-2-yl)anilines Leading to Divergent Syntheses of Benzo[α]carbazole, Benzo[c,h]cinnoline and Dibenzo[i]phenanthridine Derivatives

A gold(I)-catalyzed 6-endo-dig cyclization of aromatic 1,5-enynes was developed to synthesize 2-(naphthalen-2-yl)anilines. The functional group tolerance of this cyclization was examined systematically and a possible mechanism was proposed. The derivatization of 2-(naphthalen-2-yl)aniline was carried out to facile access to benzo[α]carbazole, benzo[c,h]cinnoline and dibenzo[i]phenanthridine derivatives in a divergent way.

Palladium-catalyzed cascade decarboxylative amination/6- endo-dig benzannulation of o-alkynylarylketones with n-hydroxyamides to access diverse 1-naphthylamine derivatives

An efficient and practical one-pot strategy to produce highly substituted 1-naphthylamines via sequential palladium-catalyzed decarboxylative amination/intramolecular 6-endo-dig benzannulation reactions has been described. In this reaction, a broad range of electron-rich, electron-neutral, and electron-deficient o-alkynylarylketones react well with N-hydroxyl aryl/alkylamides to give a diversity of 1-naphthylamines in good to excellent yields under mild reaction conditions. The gram-scale synthesis, with benefits such as undiminished product yield and easy transformation, illustrated the practicality of this method.

Palladium-Catalyzed Dialkylation of C-C Triple Bonds: Access to Multi-Functionalized Indenes

A palladium-catalyzed dialkylation of 1,3-dien-5-ynes was developed using alkenyl double bonds as the initiator and terminator for the synthesis of functionalized indene derivatives. The reactions were performed under mild reaction conditions, affording the corresponding multi-substituted indene derivatives in high efficiency via unprecedented 5-endo cyclization and alkylation processes. It was found that the substituent location at the alkenyl double bond was essential for the chemoselective synthesis of the indene and naphthalene derivatives, respectively.