Antioxidant activity of some ascorbic and cinnamic acids derivatives

Article abstract of DOI:10.1016/S0014-827X(97)00012-8

Some 4-benzoyl 3-hydroxy furan-2 (5H) ones (3a-d) and 2-amino 3-hydroxymethyl 4-aryl 4-oxo 2-butenoic acids (4a-h) have been synthesized. Compound 3c with an isobutyl substituent in the 5-position of the furan ring was the most effective (IC₅₀ = 8.69 x 10^-4 M) in scavenging the superoxide anion. In vivo, 3c was also protective against reperfusion injury.