Il Farmaco p. 85 - 88 (1998)
Update date:2022-08-11
Topics:
Point, Dominique
Coudert, Pascal
Leal, Fernand
Rubat, Catherine
Sautou-Miranda, Valerie
Chopineau, Jean
Couquelet, Jacques
Some 4-benzoyl 3-hydroxy furan-2 (5H) ones (3a-d) and 2-amino 3-hydroxymethyl 4-aryl 4-oxo 2-butenoic acids (4a-h) have been synthesized. Compound 3c with an isobutyl substituent in the 5-position of the furan ring was the most effective (IC50 = 8.69 x 10-4 M) in scavenging the superoxide anion. In vivo, 3c was also protective against reperfusion injury.
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