74829-95-1

Basic information

• Product Name: Cyclohexanesulfinic acid, sodium salt
• CAS NO: 74829-95-1
• Molecular Formula: C6H12O2S.Na
• Molecular Weight: 170.208
• Mol File: 74829-95-1.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Cyclohexanesulfinic acid, sodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanesulfinic acid, sodium salt(74829-95-1)
• EPA Substance Registry System: Cyclohexanesulfinic acid, sodium salt(74829-95-1)

Safety Data

• Hazardous Substances Data: 74829-95-1(Hazardous Substances Data)

Upstream product

• 116709-95-6 3-cyclohexanesulfonyl-propionic acid 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 860427-46-9 cyclohexanesulfonyl-succinic acid 
• 1569-69-3 Cyclohexanethiol 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 4837-38-1 cyclohexanesulfonyl chloride 
• 60372-32-9 2-(cyclohexylthio)benzo[d]thiazole 
• 141-52-6 sodium ethanolate 
• 94055-54-6 2-nitrophenyl cyclohexanethiosulfonate 
• 95091-06-8 2-cyclohexanesulfonyl-benzothiazole 
• 123-54-6 acetylacetone 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 104449-93-6 (butylsulfonyl)cyclohexane 
• 28797-07-1 dicyclohexyl sulfone 
• 34008-96-3 cyclohexyl ethyl sulfone 
• 60260-74-4 (methylsulfonyl)cyclohexane 
• 74829-85-9 (E)-(2-(cyclohexylsulfonyl)vinyl)benzene 
• 74829-84-8 ((E)-3,3-Dimethyl-but-1-ene-1-sulfonyl)-cyclohexane 
• 50366-54-6 3-Cyclohexanesulfonyl-1-phenyl-propan-1-one 
• 1174009-26-7 2-(cyclohexylsulfonyl)benzaldehyde 
• 6947-57-5 cyclohexyl phenyl sulfone 

Relevant articles and documents

Copper-Catalyzed Enantioselective Construction of Tertiary Propargylic Sulfones

Tertiary propargylic sulfones are of significant importance in organic synthesis and medicinal chemistry, but to date no general asymmetric synthesis approach has been developed. We disclose a versatile copper-catalyzed sulfonylation of propargylic cyclic carbonates using sodium sulfinates that allows the construction of propargylic sulfones featuring elusive quaternary stereocenters. This method provides the first successful example of such an enantioselective propargylic sulfonylation, features high asymmetric induction, wide functional group tolerance, and scalability, and enables attractive product diversification.

Regio- and Enantioselective Preparation of Chiral Allylic Sulfones Featuring Elusive Quaternary Stereocenters

We describe here the first general asymmetric synthesis of sterically encumbered α,α-disubstituted allylic sulfones via Pd-catalyzed allylic substitution. The design and application of a new and highly efficient phosphoramidite ligand (L10) proved to be crucial, and a wide variety of challenging allylic sulfones featuring quaternary stereocenters could be obtained in good yields and with good to excellent levels of regio- and enantioselectivities under attractive process conditions. The developed methodology employs easily accessible chemical feedstock including racemic allylic precursors and sodium sulfinates. The utility of the method is further demonstrated by the synthesis of the sesquiterpene (?)-Agelasidine A.

Eosin Y (EY) Photoredox-Catalyzed Sulfonylation of Alkenes: Scope and Mechanism

Alkyl- and aryl vinyl sulfones were obtained by eosin Y (EY)-mediated visible-light photooxidation of sulfinate salts and the reaction of the resulting S-centered radicals with alkenes. Optimized reaction conditions, the sulfinate and alkene scope, and X-ray structural analyses of several reaction products are provided. A detailed spectroscopic study explains the reaction mechanism, which proceeds through the EY radical cation as key intermediate oxidizing the sulfinate salts.