74857-56-0Relevant academic research and scientific papers
Desulfurative Ni-Catalyzed Reductive Cross-Coupling of Benzyl Mercaptans/Mercaptoacetates with Aryl Halides
Chan, Cheng-Lin,Hsu, Che-Ming,Lee, Shao-Chi,Li, Li-Yun,Liao, Hsuan-Hung,Mi?oza, Shinje,Tsai, Hao-En,Tsai, Zong-Nan,Tsao, Yong-Ting
, (2022/02/07)
The C-S activation and sulfur removal from native thiols is challenging, which limits their application as feedstock materials in organic synthesis despite their natural abundance. Herein, we introduce a per-/polyfluoroaryl moiety, which serves as a redox-active scaffold, into sp3-hybridized thiols to activate the C-S bond. Using a Ni catalyst with MgBr2 as an additive, the S group can be removed to yield an aliphatic radical that can react with an aryl halide in a reductive cross-coupling.
Multifunctional oxygen vacancies in WO3–x for catalytic alkylation of C–H by alcohols under red-light
Gu, Xianmo,Sun, Xichen,Wang, Yunwei,Zhang, Jin,Zheng, Zhanfeng,Zhu, Pengqi
, p. 208 - 217 (2021/09/06)
Surface reaction kinetics and light absorption properties of a photocatalyst are essential demands for efficiently solar to chemical energy converting. In this study, plasmonic WO3–x was firstly applied to photocatalytic alkylation of arenes under red light irradiation. The oxygen vacancies, both on the surface and in the bulk of WO3–x, allow abundant free electrons to increase carrier densities and support its LSPR using low energy photons. The surface oxygen vacancies have more functions: they not only release surface tungsten sites which ensure the chemisorption of alcohols due to the coordianation ability but also promote the activation of alcohols via an efficient transport of the holes on the neighbouring O sites to chemisorption alcohol species. In brief, the bulk oxygen vacancies provide abundant charges and the surface vacancies promote the bond adsorption and activation abilities, which ensure the high efficiency of photocatalytic alkylation of C–H.
Synthesis and characterization of imine-palladacycles containing imidate "pseudohalide" ligands: Efficient Suzuki-Miyaura cross-coupling precatalysts and their activation to give Pd0Ln species (L = Phosphine)
Serrano, Jose Luis,Garcia, Luis,Perez, Jose,Perez, Eduardo,Garcia, Joaquin,Sanchez, Gregorio,Sehnal, Petr,De Ornellas, Sara,Williams, Thomas J.,Fairlamb, Ian J. S.
experimental part, p. 5095 - 5109 (2011/11/14)
Dinuclear palladacyclic complexes [{Pd(C^N)(μ-NCO)} 2] (C^N = N-phenylbenzaldimine, Phbz) containing asymmetric imidato units (-NCO- = succinimidate (succ; 1), phthalimidate (phthal; 2), maleimidate (mal; 3), 2,3-dibromomaleimidate (2,3-diBrmal; 4), glutarimidate (glut; 5)) have been readily prepared by reaction between the di-μ-acetate precursor and cyclic imide ligands in a 1:2 molar ratio. Base treatment of the less acidic ligands 2-oxazolidone and δ-valerolactame with KOH/MeOH was required to give analogous -NCO- bridged complexes (6 and 7). Reactions of the dinuclear complexes with tertiary phosphines provide novel mononuclear N-bonded imidate derivatives of the general formula [Pd(Phbz)(imidate)(PR3)] (R = Ph (a), 4-F-C6H4 (b), 4-MeO-C6H4 (c), CH2CH2CN (d)). The application of these novel palladacyclic complexes as precatalysts for the Suzuki-Miyaura cross-coupling reactions of both aryl and benzyl bromides with phenylboronic acid has been examined. The acetate adducts [Pd(Phbz)(CH 3COO)(PR3)] (8a,c) were prepared to assess the role of imidate ligands in catalyst performance. The mononuclear imidate derivatives possess greater activity than the parent dinuclear complexes, exhibiting comparable performance in the cross-coupling of benzyl bromide with arylboronic acids to the best examples reported in the literature. The mononuclear imidate derivatives give a common Pd0Ln intermediate, as inferred by the release of the organic fragment (first reductive elimination product). Catalyst activation occurs by reaction of phenylboronic acid with the palladacycle in the absence of exogenous base (as shown by GC-MS and ESI-MS), with implications for the reliable comparison of catalyst performance across a series of related precatalysts (e.g., how catalyst/reagents are mixed and what is their order of addition). The single-crystal X-ray structures of compounds 4, 7, 1d, 3c, and 8a have been determined.
Aza-and polyaza-naphthalenly ketones useful as hiv integrase inhibitors
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Page/Page column 48, (2010/02/10)
Certain aza- and polyaza-naphthalenyl ketones including certain quinolinyl and naphthyridinyl ketones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment or the delay in the onset of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.
1-(Aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof
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, (2010/02/06)
Certain 1-(aromatic- or heteroaromatic-substituted-3-(heteroaromatic substituted)-1,3-propanediones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
Highly active catalyst for the heterogeneous Suzuki-Miyaura reaction: Assembled complex of palladium and non-cross-linked amphiphilic polymer
Yamada, Yoichi M. A.,Takeda, Koji,Takahashi, Hideyo,Ikegami, Shiro
, p. 7733 - 7741 (2007/10/03)
An assembled insoluble catalyst, PdAS, prepared from palladium ((NH 4)2PdCl4 (1)) and non-cross-linked amphiphilic copolymer poly(N-isopropylacrylamide-co-4-diphenylstyrylphosphine) (2) was developed. It was found that PdAS is an excellent catalyst for the Suzuki-Miyaura reaction on three points: (1) The use of 8 × 10 -7 to 5 × 10-4 mol equiv of PdAS afforded the coupling products efficiently after easy workup, with the turnover number reaching up to 1 250 000. (2) The catalyst was reusable many times without loss of catalytic activity. (3) PdAS showed good stability in any reaction medium (i.e., water or aqueous or anhydrous organic solvents). Analytical study of PdAS indicates that the phosphines in 2 coordinate to palladium to form PdCl2(PPh2Ar)2 species.
ELECTROCHEMICAL REDUCTIVE ACYLATION OF (η6-arene)Cr(CO)3 COMPLEXES AND (benzphenone)2
Degrand, C.,Bikrani, M.,Gautheron, B.
, p. 111 - 118 (2007/10/02)
The electrochemical reductive acylation of (benzophenone)Cr(CO)3 and (benzophenone)2 has been performed in DMF, by electrochemical reduction of complexed ketones in the presence of acetic and benzoic anhydride in excess.Three complexed benzhydryl
