7496-04-0

Usage

Uses

Used in Organic Synthesis:
(2-methylphenyl)(naphthalen-2-yl)methanone is used as a synthetic intermediate for the development of various organic compounds, leveraging its unique structure and reactivity in chemical reactions.
Used in Chemical Research:
As a novel ketone derivative, (2-methylphenyl)(naphthalen-2-yl)methanone is utilized in chemical research to explore its properties, reactivity, and potential as a building block for new chemical entities.
Used in Pharmaceutical Development:
(2-methylphenyl)(naphthalen-2-yl)methanone may be employed in pharmaceutical development as a starting material or a component in the synthesis of new drug candidates, given its structural features that could be relevant for medicinal chemistry applications.
Caution should be exercised when handling and using (2-methylphenyl)(naphthalen-2-yl)methanone due to the lack of comprehensive information on its specific properties and potential hazards.

Upstream product

• 932-31-0 ortho-tolylmagnesium bromide 
• 613-46-7 2-naphthalenecarbonitrile 
• 412300-61-9 2-o-toluoyl-[1]naphthoic acid 
• 91-20-3 naphthalene 
• 933-88-0 ortho-toluoyl chloride 
• 201230-82-2 carbon monoxide 
• 16419-60-6 2-Methylphenylboronic acid 
• 450-58-8 2-naphthyldiazonium tetrafluoroborate 
• 5343-99-7 1,2-naphthalenedicarboxylic anhydride 
• 108-88-3 toluene 
• 93-09-4 naphthalene-2-carboxylate 
• 84109-17-1 2-methylphenylzinc chloride 
• 2243-82-5 2-naphthamide 
• 95-46-5 2-methylphenyl bromide 

Downstream Products

• 66778-24-3 2-(2-methylphenyl)naphthalene 

Relevant academic research and scientific papers

Nickel-mediated decarbonylation of simple unstrained ketones through the cleavage of carbon-carbon bonds

Despite advances in methods for the decarbonylation of aldehydes, the decarbonylation of ketones has been met with limited success because this process requires the activation of two inert carbon-carbon bonds. All of the decarbonylation reactions of simple unstrained ketones reported to date require the addition of a stoichiometric rhodium complex. We report herein the nickel/N-heterocyclic carbene-mediated decarbonylation of simple diaryl ketones. This reaction shows unique acceleration effects based on the presence of both electron-donating and electron-withdrawing groups.

Nickel-catalyzed diaryl ketone synthesis by N-C cleavage: Direct negishi cross-coupling of primary amides by site-selective N,N-Di-boc activation

A general Negishi acylation of primary amides enabled by a combination of site-selective N,N-di-Boc activation and nickel catalysis is reported for the first time. The reaction is promoted by a bench-stable, inexpensive Ni catalyst. The reaction shows excellent functional group compatibility, affording functionalized diaryl ketones by selective N-C cleavage. Most notably, this protocol represents the first amide cross-coupling by direct metal insertion of simple and readily available primary amides. The overall strategy by N,N-di-Boc activation/metal insertion is suitable for a broad range of coupling protocols via acylmetals. Mechanistic experiments suggest high reactivity of N,N-di-Boc activated 1° amides in direct amide C-N cross-couplings.

Erbium trifluoromethanesulfonate catalyzed Friedel-Crafts acylation using aromatic carboxylic acids as acylating agents under monomode-microwave irradiation

Erbium trifluoromethanesulfonate is found to be a good catalyst for the Friedel-Crafts acylation of arenes containing electron-donating substituents using aromatic carboxylic acids as the acylating agents under microwave irradiation. An effective, rapid and waste-free method allows the preparation of a wide range of aryl ketones in good yields and in short reaction times with minimum amounts of waste.

Palladium-imidazolium-catalyzed carbonylative coupling of aryl diazonium ions and aryl boronic acids

Palladium(II) acetate and N,N-bis-(2,6-diisopropylphenyl)dihydroimidazolium chloride (2 mol%) were used to catalyze the carbonylative coupling of aryl diazonium tetrafluoroborate salts and aryl boronic acids to form aryl ketones. Optimal conditions includ