7517-07-9

Basic information

• Product Name: 1-(4-HYDROXYPHENYL)PYRROLIDIN-2-ONE
• Synonyms: 1-(4-HYDROXYPHENYL)PYRROLIDIN-2-ONE;1-(4-hydroxyphenyl)-2-pyrrolidinone(SALTDATA: FREE);1-(4-hydroxyphenyl)-2-pyrrolidinone;1-(4-hydroxyphenyl)-2-pyrrolidone;SBB015086;ZINC00282290
• CAS NO: 7517-07-9
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.2
• Mol File: 7517-07-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 459.8°C at 760 mmHg
• Flash Point: 231.9°C
• Appearance: /
• Density: 1.275g/cm³
• Vapor Pressure: 4.49E-09mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: 1-(4-HYDROXYPHENYL)PYRROLIDIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-HYDROXYPHENYL)PYRROLIDIN-2-ONE(7517-07-9)
• EPA Substance Registry System: 1-(4-HYDROXYPHENYL)PYRROLIDIN-2-ONE(7517-07-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 7517-07-9(Hazardous Substances Data)

Usage

General Description

1-(4-Hydroxyphenyl)pyrrolidin-2-one is a chemical compound with the molecular formula C11H11NO2. It is a pyrrolidone derivative with a hydroxyl group attached to the phenyl ring at the 4 position. This chemical is commonly used as a building block in the synthesis of pharmaceuticals and natural products. It has been studied for its potential use as an antioxidant and anti-inflammatory agent due to its phenolic structure. Additionally, it has been investigated for its potential use in the treatment of neurodegenerative diseases. Overall, 1-(4-Hydroxyphenyl)pyrrolidin-2-one is a versatile compound with potential applications in various fields of research and industry.

InChI:InChI=1/C10H11NO2/c12-9-5-3-8(4-6-9)11-7-1-2-10(11)13/h3-6,12H,1-2,7H2

Upstream product

• 96-48-0 4-butanolide 
• 123-30-8 4-amino-phenol 
• 439148-58-0 1-(4-(benzyloxy)phenyl)pyrrolidin-2-one 
• 540-38-5 p-Iodophenol 
• 19578-68-8 4-(4-benzyloxyphenyl) iodide 
• 4635-59-0 4-Chlorobutanoyl chloride 
• 616-45-5 2-pyrrolidinon 
• 71597-85-8 (p-hydroxyphenyl)boronic acid 

Downstream Products

• 897026-59-4 (R/S)-3-(5-benzyloxy-3-chloro-2-methoxyphenyl)-5-(3-(4-(2-oxopyrrolidin-1-yl)phenyloxy)propyl)-Δ²-isoxazoline 
• 14053-16-8 1-(4-acetoxy-phenyl)-pyrrolidin-2-one 
• 30425-47-9 N-(4-methoxyphenyl)-2-pyrrolidinone 

Relevant articles and documents

Synthesis of N -Aryl and N -Heteroaryl γ-, δ-, and ?-Lactams Using Deprotometalation-Iodination and N -Arylation, and Properties Thereof

Xanthone, thioxanthone, fluorenone, benzophenone, 2-benzoylpyridine, dibenzofuran, and dibenzothiophene were deprotonated using a base prepared in situ from MCl 2 ·TMEDA (M = Zn or Cd; TMEDA = N, N, N ′, N ′-tetramethylethylenediamine) and lithium 2,2,6,6-tetramethylpiperidide in a 1:3 ratio, as demonstrated by subsequent iodolysis. The different aryl halides were involved as partners in the N -arylation of pyrrolidin-2-one. In the presence of copper(I) iodide and tripotassium phosphate, and using dimethyl sulfoxide as solvent, the reactions could be performed in yields ranging from 40 to 70%. Most of the products were tested for their antimicrobial, antifungal, antioxidant, and cytotoxic (MCF-7) activity.

Synthesis of a new family of N-aryl lactams active on chemesthesis and taste

A new class of synthetic compounds with chemesthetic activity has been identified. They have been designed ex-novo by structural similarity with known cooling compounds such as menthol, icilin and cyclic ketoenamines. 19 new derivatives have been obtained