7529-63-7

Basic information

• Product Name: Piperidine, 1-(1-phenylethyl)-
• CAS NO: 7529-63-7
• Molecular Formula: C13H19N
• Molecular Weight: 189.301
• Mol File: 7529-63-7.mol
• Article Data: 44

Chemical Properties

• CAS DataBase Reference: Piperidine, 1-(1-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 1-(1-phenylethyl)-(7529-63-7)
• EPA Substance Registry System: Piperidine, 1-(1-phenylethyl)-(7529-63-7)

Safety Data

• Hazardous Substances Data: 7529-63-7(Hazardous Substances Data)

Upstream product

• 111-24-0 1,5-dibromo-pentane 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 110-89-4 piperidine 
• 64-18-6 formic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 98-86-2 acetophenone 
• 585-71-7 (1-bromoethyl)benzne 
• 660-88-8 5-aminopentanoic acid 
• 5351-11-1 1-(butoxyphenylmethyl)piperidine 
• 74-88-4 methyl iodide 
• 100-42-5 styrene 
• 5542-49-4 piperidin-1-yl benzoate 
• 14990-66-0 1-(1-phenylvinyl)piperidine 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 879932-62-4 1-(1-phenylethyl)piperidin-2-one 
• 912358-35-1 1-[(1S)-1-phenylethyl]piperidine-2-carbonitrile 
• 1026458-67-2 1,1,1-Trifluoro-3-[2-((S)-1-piperidin-1-yl-ethyl)-benzenesulfonyl]-propan-2-ol 
• 192209-50-0 1-{(S)-1-[2-((E)-3,3,3-Trifluoro-prop-1-ene-1-sulfonyl)-phenyl]-ethyl}-piperidine 

Relevant articles and documents

Cleavage∕cross-coupling strategy for converting β-O-4 linkage lignin model compounds into high valued benzyl amines via dual C–O bond cleavage

Lignin is the most recalcitrant of the three components of lignocellulosic biomass. The strength and stability of the linkages have long been a great challenge for the degradation and valorization of lignin biomass to obtain bio-fuels and commercial chemicals. Up to now, the selective cleavage of C–O linkages of lignin to afford chemicals contains only C, H and O atoms. Our group has developed a cleavage/cross-coupling strategy for converting 4-O-5 linkage lignin model compounds into high value-added compounds. Herein, we present a palladium-catalyzed cleavage/cross-coupling of the β-O-4 lignin model compounds with amines via dual C–O bond cleavage for the preparation of benzyl amine compounds and phenols.

Copper-Catalyzed Carbonylative Hydroamidation of Styrenes to Branched Amides

Amides are one of the most ubiquitous functional groups in synthetic and medicinal chemistry. Novel and rapid synthesis of amides remains in high demand. In this communication, a general and efficient procedure for branch-selective hydroamidation of vinylarenes with hydroxyamine derivatives enabled by copper catalysis has been developed for the first time. The reaction proceeds under mild conditions and tolerates a broad range of functional groups. Applying a chiral phosphine ligand, an enantioselective variant of this transformation was achieved, affording a variety of chiral α-amides with excellent enantioselectivities (up to 99 % ee) and high yields.

Formal Synthesis of (–)-Perhydrohistrionicotoxin Using a Thorpe-Ziegler Cyclization Approach. Synthesis of Functionalized Aza-Spirocycles

The formal synthesis of (–)-PHTX is described. Our approach was based on the anodic cyanation of (S)-1-(1-phenylethyl)-piperidine (–)-1 to afford α-aminonitrile 2 in 85 % yield in a 53:47 dr. The presence of the α-phenylethyl group as the chiral auxiliary