7540-93-4

Basic information

• Product Name: 2-hydroxy-1,2,3-triphenylpropan-1-one
• Synonyms: 1-propanone, 2-hydroxy-1,2,3-triphenyl-; 2-Hydroxy-1,2,3-triphenylpropan-1-one
• CAS NO: 7540-93-4
• Molecular Formula: C₂₁H₁₈O₂
• Molecular Weight: 302.3664
• Mol File: 7540-93-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 472.1°C at 760 mmHg
• Flash Point: 200.7°C
• Density: 1.175g/cm³
• Vapor Pressure: 1.02E-09mmHg at 25°C
• Refractive Index: 1.625
• CAS DataBase Reference: 2-hydroxy-1,2,3-triphenylpropan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-1,2,3-triphenylpropan-1-one(7540-93-4)
• EPA Substance Registry System: 2-hydroxy-1,2,3-triphenylpropan-1-one(7540-93-4)

Safety Data

• Hazardous Substances Data: 7540-93-4(Hazardous Substances Data)

Upstream product

• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 134-81-6 benzil 
• 6921-34-2 benzylmagnesium chloride 
• 451-40-1 phenyl benzyl ketone 
• 100-39-0 benzyl bromide 
• 64-17-5 ethanol 
• 100-44-7 benzyl chloride 
• 60-29-7 diethyl ether 
• 3469-17-8 2-diazo-1,2-diphenylethan-1-one 
• 174869-02-4 α-(2-cyanoethyl)benzoin 
• 20736-40-7 2-(benzyloxy)-1,2-diphenylethanone 
• 1589-82-8 phenylmagnesium bromide 
• 4314-94-7 benzyl(trimethyl)tin 

Downstream Products

• 26595-41-5 α-Benzyl-benzoin-ethylether 
• 2430-99-1 1-phenyl-2-p-tolylethanone 
• 583-05-1 1-phenylpentane-1,4-dione 
• 174869-07-9 α-(3-oxobutyl)benzoin 
• 174869-02-4 α-(2-cyanoethyl)benzoin 
• 100-52-7 benzaldehyde 
• 95448-28-5 α-(4-methylbenzyl)benzoin 
• 5343-98-6 4-oxo-4-phenylbutanenitrile 
• 91-01-0 1,1-Diphenylmethanol 
• 5773-56-8 1,2-Diphenylethanol 
• 65-85-0 benzoic acid 
• 4842-45-9 1,2,3-triphenylpropan-1-one 
• 451-40-1 phenyl benzyl ketone 
• 119-53-9 2-hydroxy-2-phenylacetophenone 

Relevant articles and documents

Photo-allylation and photo-benzylation of carbonyl compounds using organotrifluoroborate reagents

Allyl- and benzyl-trifluoroborates can be applied to the photoreaction of carbonyl compounds to afford the corresponding alcoholic adducts in acceptable yields via a photo-induced single electron transfer pathway. The results were confirmed from the react

Carbon-carbon bond cleavage of α-substituted benzoins by retro-benzoin condensation; A new method of synthesizing ketones

When α-benzylbenzoin (3a, α-benzyl-α-hydroxybenzyl phenyl ketone) was treated with potassium cyanide (1) in N,N-dimethylformamide at 80°C for 1h, the carbon-carbon bond was cleaved, resulting in the formation of deoxybenzoin (4a, benzyl phenyl ketone) and benzaldehyde (2a). This carbon- carbon bond cleavage proceeds through a retro-benzoin condensation mechanism. This method of synthesizing ketones was applied to several α-substituted benzoins (3), and the corresponding ketones (4) were formed in good yields. Further, we found that the cyanide ion-donating ability of tetrabutylammonium cyanide (6, Bu4NCN) is more effective than that of potassium cyanide (1, KCN). As expected from the chemical analogy between cyanide ion and azolium ylide, several azolium salts (7) can also be employed in the retro-benzoin condensation as catalysts. The benzoin derivatives 3 were synthesized in the following three ways; reaction of alkyl halide (9) with benzoin (5), Michael addition of benzoin (5) with acceptors (10), and Grignard reaction of benzils (8). Alkylation of the benzoins without isolation, followed by carbon-carbon bond cleavage, readily afforded the corresponding ketones (4).

Asymmetric Synthesis of the Methyl and Benzyl Ethers of erythro-α,β-Diphenyl-β-hydroxyethanol and erythro-α,β-Diphenyl-β-hydroxyethylamine from (+)-(S)-Benzoin

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