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Usage

Uses

Used in Pharmaceutical Industry:
4-(TRIFLUOROMETHYLSULFONYL)CHLOBENZENE is used as an intermediate for the synthesis of pharmaceuticals, contributing to the development of new drugs and medicines. Its stable chemical structure allows for the creation of a wide range of therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(TRIFLUOROMETHYLSULFONYL)CHLOBENZENE is utilized as an intermediate in the production of various agrochemicals. This helps in the development of effective solutions for pest control and crop protection.
Used in Organic Synthesis:
4-(TRIFLUOROMETHYLSULFONYL)CHLOBENZENE is used as a reagent in organic synthesis, enabling the creation of a diverse array of organic compounds for different applications.
Used in Chemical Production:
As a building block, 4-(TRIFLUOROMETHYLSULFONYL)CHLOBENZENE is employed in the production of other chemicals, expanding its utility across various chemical industries.
Safety Precautions:
Due to its classification as a hazardous substance, it is crucial to follow appropriate safety measures when handling and using 4-(TRIFLUOROMETHYLSULFONYL)CHLOBENZENE to ensure the well-being of individuals and the environment.

Upstream product

• 84796-67-8 C₇H₄ClF₃N₂O₂S 
• 2314-97-8 iodotrifluoromethane 
• 100-03-8 4-chlorobenzenesulfinic acid 
• 98-64-6 4-Chlorobenzenesulfonamide 
• 112425-78-2 S-(trifluoromethyl)diphenylsulfonium tetrafluoroborate 
• 14752-66-0 sodium p-chlorobenzenesulphinate 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 108-90-7 chlorobenzene 
• 2926-29-6 Langlois reagent 
• 1961266-44-3 2,8-difluoro-5-(trifluoromethyl)-5H-dibenzo[b,d]thiophen-5-ium trifluoromethanesulfonate 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 1204518-00-2 (4-chlorophenyl)(mesityl)iodonium trifluoromethanesulfonate 
• 75-46-7 trifluoromethan 
• 349-89-3 p-chlorobenzenesulfonyl fluoride 

Downstream Products

• 1550-27-2 1-chloro-2-nitro-4-[(trifluoromethyl)sulfonyl]benzene 
• 4837-29-0 p-trifluoromethylsulfonylphenylhydrazine 
• 15183-74-1 1-methoxy-4-((trifluoromethyl)sulfonyl)benzene 
• 5857-42-1 4-methoxybenzenesulfonic acid 
• 37552-84-4 methyl (4-((trifluoromethyl)sulfonyl)phenyl)sulfane 
• 98-66-8 4-chloro-benzenesulfonic acid 
• 17162-46-8 Bis-(4-trifluormethylsulfonyl-phenyl)-disulfid 
• 13607-64-2 1-(dimethylamino)-4-(trifluoromethyl)sulfonylbenzene 
• 98-57-7 4-chlorophenyl methyl sulfone 
• 80-00-2 4-Chlorophenyl phenyl sulfone 
• 19822-29-8 2,6-dinitro-4-((trifluoromethyl)sulfonyl)anisole 
• 83547-68-6 1-(2-hydroxyethoxy)-2,6-dinitro-4-((trifluoromethyl)sulfohyl)benzene 
• 810-43-5 bis-(2-nitro-4-trifluoromethanesulfonyl-phenyl)-disulfide 
• 400-23-7 2-nitro-4-trifluoromethylsulfonyl-phenylamine 

Relevant academic research and scientific papers

Synthesis, Reactivity and Structural Properties of Trifluoromethylphosphoranides

Phosphoranides are interesting hypervalent species which serve as model compounds for intermediates or transition states in nucleophilic substitution reactions at trivalent phosphorus substrates. Herein, the syntheses and properties of stable trifluoromet

Transition-Metal-Free Synthesis of Aryl Trifluoromethyl Thioethers through Indirect Trifluoromethylthiolation of Sodium Arylsulfinate with TMSCF3

Herein, we report an indirect trifluoromethylthiolation of sodium arylsulfinates. This transition-metal-free reaction significantly provides an environmentally friendly and practical synthetic method for aryl trifluoromethyl thioethers using commercial Ruppert-Prakash reagent TMSCF3. This approach is also a potential alternative to the current industrial production method owing to facile substrates, excellent functional group compatibility, and operational simplicity.

Practical and efficient synthesis of aryl trifluoromethyl sulfones from arylsulfonyl chlorides with Umemoto's reagent II

A practical and efficient method for the synthesis of aryl trifluoromethyl sulfones has been developed by a tandem reaction of arylsulfonyl chlorides with Umemoto's reagent II. The advantageous features of this method are simple operation, mild reaction conditions, wide scope of substrates, high yield of products, and easy scalability.

Synthesis of Aryl Triflones through the Trifluoromethanesulfonylation of Benzynes

The direct synthesis of aryl triflones, that is, trifluoromethanesulfonyl arenes, was achieved through the trifluoromethanesulfonylation of benzynes. The trifluoromethanesulfonyl group, one of the fluorinated functional groups, is a highly electron-negative and mild lipophilic substituent. Aryl triflones have high potential in the synthesis of bioactive compounds and specialty materials. The treatment of 2-(trimethylsilyl)aryl trifluoromethanesulfonates with cesium fluoride in the presence of 15-crown-5 generated benzynes, which reacted with sodium trifluoromethanesulfinate followed by protonation with tBuOH under heating conditions, provided aryl triflones in moderated to good yields. Both symmetrical and unsymmetrical triflones were nicely accessed under the same reaction conditions. Interestingly, the trifluoromethanesulfonylation of unsymmetrical benzyne precursors proceeded smoothly to furnish corresponding aryl triflones in good yields with good to high regioselectivities. The balance of polarization of electric charge as well as steric hindrance of the benzyne intermediates are central factors to control the outcome of regioselectivity.

A method of manufacturing a benzene derivative (trifluoromethylsulfonyl)

PROBLEM TO BE SOLVED: To provide a method for producing a (trifluoromethylsulfonyl)benzene derivative which is useful as a medicine, an agricultural chemical, a functional material and a production intermediate thereof. SOLUTION: In this method, a (trifluoromethylsulfonyl)benzene derivative is produced by reacting diaryliodonium salt represented by general formula (1) with trifluoromethanesulfinic acid salt in the presence of a copper (I) salt. (In the formula, R1, R2, R3, R4, R5, R6, R7, R8, R9and R10each independently represents a hydrogen atom, a 1-6C alkyl group, a 1-6C haloalkyl group, a 1-6C alkoxy group, a 2-6C acyl group, (1-5C alkoxy)carbonyl group, a nitro group, a cyano group, a chlorine atom or a bromine atom). COPYRIGHT: (C)2013,JPOandINPIT

METHOD FOR PRODUCING TRIFLUOROMETHYLSULFONYL COMPOUND DERIVATIVE

PROBLEM TO BE SOLVED: To provide a method for producing a trifluoromethylsulfonyl compound derivative useful as synthetic intermediates for medicines and agrochemicals. SOLUTION: The method for producing a trifluoromethylsulfonyl compound derivative repre

Organocatalyzed Trifluoromethylation of Ketones and Sulfonyl Fluorides by Fluoroform under a Superbase System

Fluoroform (HCF3, HFC-23) is a side product in the manufacture of polytetrafluoroethylene (Teflon). Despite its attractive properties, taming HCF3 for trifluoromethylation is quite problematic owing to its low acidity and the labilit

A new method for the synthesis of trifluoromethylating agents-Diaryltrifluoromethylsulfonium salts

A new synthetic method has been developed to prepare diaryltrifluoromethylsulfonium salts from diaryldifluorosulfuranes by the action of Me3SiCF3/F-. This reaction is the transformation of nucleophilic trifluoro-methylating reagent into electrophilic one.

PREPARATION AND FLUORINATION OF ARYLTRIFLUOROMETHYLSULPHONES

A series of chloro- and nitrophenyl trifluoromethyl sulphides and sulphones have been synthesised from the corresponding aryl halides .The fluorination of these compounds by tetra-n-butyl ammonium fluoride and potassium fluoride has been investigated.Our results show that generally they are more susceptible to fluorodenitration than fluorodechlorination.

A convenient route to aryl trifluoromethyl sulfones by fluoride-catalyzed cross-coupling of arenesulfonyl fluorides with (trifluoromethyl)trimethylsilane and (trifluoromethyl)trimethylstannane

Trifluoromethylsulfonyl substituted aromatic compounds 3a-d are prepared from the corresponding sulfonyl fluorides 1a-d by reacting with (trifluoromethyl)trimethylsilane (or-stannane) in the presence of a base under mild conditions in high yields.