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1-trifluoromethyl-1,2-diphenylethylene is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

76280-44-9

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76280-44-9 Usage

Synthesis Reference(s)

Tetrahedron Letters, 37, p. 171, 1996 DOI: 10.1016/0040-4039(95)02118-3

Check Digit Verification of cas no

The CAS Registry Mumber 76280-44-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,2,8 and 0 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 76280-44:
(7*7)+(6*6)+(5*2)+(4*8)+(3*0)+(2*4)+(1*4)=139
139 % 10 = 9
So 76280-44-9 is a valid CAS Registry Number.

76280-44-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name [(E)-3,3,3-trifluoro-1-phenylprop-1-en-2-yl]benzene

1.2 Other means of identification

Product number -
Other names 1,1-Tfmde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:76280-44-9 SDS

76280-44-9Downstream Products

76280-44-9Relevant academic research and scientific papers

Synthesis of (Z)-α-Trifluoromethyl Alkenyl Triflate: A Scaffold for Diverse Trifluoromethylated Species

Zhao, Yilong,Zhou, Yuhan,Liu, Juan,Yang, Dongmei,Tao, Liang,Liu, Yang,Dong, Xiaoliang,Liu, Jianhui,Qu, Jingping

, p. 4797 - 4806 (2016/07/06)

An efficient method for the synthesis of (Z)-selective α-trifluoromethyl alkenyl triflates is described. As an important fluorinated building block, it is utilized successfully for the synthesis of various trifluoromethyl derivatives such as diarylethylen

Wittig Reactions of Phosphonium Ylides Bearing the Phosphastibatriptycene Skeleton with Carbonyl Compounds

Uchiyama, Yosuke,Murakami, Rikiya,Sugimoto, Jun

, p. 633 - 637 (2016/01/15)

To investigate effects of the tridentate ligand on the reactivity of a 1,2-oxaphosphetane, an intermediate of the Wittig reaction, the reactions of phosphonium ylides 1 and 2 bearing the phosphastibatriptycene skeleton with carbonyl compounds have been conducted and compared with those of triphenyl phosphorus compounds. Non-stabilized and semi-stabilized phosphonium ylides 1 and 2 bearing the tridentate ligand were generated from the corresponding phosphonium salts 3 and 4, which were prepared by the reactions of a phosphastibatriptycene with ethyl iodide and benzyl bromide, respectively. The reactions of ylides 1 and 2 with benzaldehyde showed high E-selectivity, in sharp contrast to those of triphenylphosphonium ylides 5 and 6 giving Z-alkenes as a major product. However, the reaction of 1 with trifluoroacetophenone gave E/Z-alkenes 10 in the ratio of 69:31 together with phosphine oxide 13, which showed slightly higher selective E-alkene formation compared with the reaction of non-stabilized ylide 5 (E/Z ratio of 51:49). The results showed that the reactions did not proceed with high stereoselectivity as same as those of semi-stabilized phosphonium ylides 2 and 6. In the VT-31P{1H} NMR spectra of the reaction mixture of non-stabilized phosphonium ylide 1 with trifluoroacetophenone, the signals due to the corresponding 1,2-oxaphosphetanes were observed as multi signals in high field around -54 ppm at -80°C, which was different from the reaction of ylide 5 showing two signals.

Pd-carbene migratory insertion: Application to the synthesis of trifluoromethylated alkenes and dienes

Wang, Xi,Xu, Yan,Deng, Yifan,Zhou, Yujing,Feng, Jiajie,Ji, Guojing,Zhang, Yan,Wang, Jianbo

supporting information, p. 961 - 965 (2014/02/14)

Pd-catalyzed cross-coupling of halides with CF3-substituted diazo compounds or N-tosylhydrazones has been explored for the synthesis of CF3-substituted alkenes and 1,3-butadienes. Pd-carbene migratory insertion plays the key role in these transformations. Copyright

One-pot multistep synthesis of trisubstituted alkenes from N -tosylhydrazones and alcohols

Sha, Qiang,Wei, Yunyang

, p. 2353 - 2361 (2014/11/08)

A one-pot procedure for the synthesis of trisubstituted alkenes from N-tosylhydrazones and alcohols is reported. This procedure combines the aerobic oxidation reaction and Wittig reaction in one pot, which avoids using of environmentally toxic oxidants and isolation of the intermediates. The simple procedure makes it very attractive for the synthesis of trisubstituted alkenes when alcohols are used as starting materials. A variety of trisubstituted alkenes as well as trifluoromethyl-substituted alkenes were obtained in moderate to good yields (up to 84%) with good E-selectivity (up to 99%). Georg Thieme Verlag Stuttgart.New York.

Copper(i)-catalyzed wittig olefination reactions of N-tosylhydrazones with trifluoromethylketones

Sha, Qiang,Wei, Yunyang

, p. 131 - 134 (2014/01/23)

Cuprous iodide-catalyzed Wittig olefination reactions of N-tosylhydrazones with trifluoromethylketones are reported. This procedure provides an efficient method for the synthesis of various trifluoromethyl-substituted alkenes in moderate to good yields (up to 89 % yield) and good stereoselectivity (up to 93 % E-selectivity). To the best of our knowledge, it is the first report of a Wittig reaction of N-tosylhydrazones with ketones. Copyright

A convenient and mild chromatography-free method for the purification of the products of Wittig and Appel reactions

Byrne, Peter A.,Rajendran, Kamalraj V.,Muldoon, Jimmy,Gilheany, Declan G.

, p. 3531 - 3537 (2012/05/20)

A mild method for the facile removal of phosphine oxide from the crude products of Wittig and Appel reactions is described. Work-up with oxalyl chloride to generate insoluble chlorophosphonium salt (CPS) yields phosphorus-free products for a wide variety of these reactions. The CPS product can be further converted into phosphine.

Efficient trifluoromethylation of activated and non-activated alkenyl halides by using (trifluoromethyl)trimethylsilane

Hafner, Andreas,Braese, Stefan

supporting information; experimental part, p. 3044 - 3048 (2012/01/02)

An efficient method for the trifluoromethylation of halogenated double bonds by using in situ generated "trifluoromethyl copper" is described. Herein, the most common trifluoromethyl source, (trifluoromethyl) trimethylsilane, was converted selectively int

Synthesis of gem-difluoroalkenes via β-fluoride elimination of organorhodium(I)

Miura, Tomoya,Ito, Yoshiteru,Murakami, Masahiro

scheme or table, p. 1006 - 1007 (2009/04/06)

Treatment of α-(trifluoromethyl)styrenes with arylboronic esters and MeMgCl in the presence of a rhodium(I) catalyst affords gem-difluoroalkenes. The reaction proceeds through the addition of arylrhodium(I) species across the electron-deficient carbon-carbon double bond and the subsequent β-fluoride elimination. Copyright

Highly regio- and stereoselective hydrometallation reactions of fluorine-containing internal alkynes: Novel approaches to fluoroalkylated alkenes

Konno, Tsutomu,Chae, Jungha,Tanaka, Tomoo,Ishihara, Takashi,Yamanaka, Hiroki

, p. 36 - 43 (2007/10/03)

Hydroalumination, hydrocupration, and hydroboration reactions of various fluorine-containing alkynes were investigated. The alkyne reacted smoothly with 2.0 equiv. of Red-Al at -78°C to give the hydroaluminated adduct in a highly regio- and stereoselectiv

Syntheses, structures, and thermolyses of pentacoordinate 1,2-oxastibetanes: Potential intermediates in the reactions of stibonium ylides with carbonyl compounds

Uchiyama, Yosuke,Kano, Naokazu,Kawashima, Takayuki

, p. 659 - 670 (2007/10/03)

Pentacoordinate 1,2-oxastibetanes 14a-d, which are formal [2 + 2]-cycloadducts of the reactions of stibonium ylides with carbonyl compounds, were successfully synthesized by the reactions of the corresponding bromo-2-hydroxyalkylstiboraiies with NaH. The

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