76579-58-3

Upstream product

• 103628-22-4 1--2-phenyl-butan-1-one 
• 104575-15-7 (benzyl)-[4-(tetrahydropyran-2-yloxy)phenyl]-ketone 
• 70354-02-8 1-<4-<(tetrahydropyran-2-yl)oxy>phenyl>-2-phenylbutan-1-one 
• 622-86-6 2-chloroethoxybenzene 
• 108-95-2 phenol 
• 119757-57-2 (E,Z)-1-<4-(2-chloroethoxy)phenyl>-1-(4-hydroxyphenyl)-2-phenyl-1-butene 
• 103628-15-5 (E)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenyl-1-butene 
• 109-89-7 diethylamine 

Relevant academic research and scientific papers

Substituted-vinyl hydroxytriarylethylenes, 1-[4-[2-(diethylamino)ethoxy]phenyl]-1-(4-hydroxyphenyl)-2-phenyl ethylenes: Synthesis and effects on MCF 7 breast cancer cell proliferation

A series of triarylethylene compounds related to 4-hydroxyclomiphene in which the vinyl Cl substituent was replaced by ethyl, Br, H (7), CN or NO2 substituents were synthesized to facilitate studies of the molecular actions of synthetic nonster

The Use of the Perfluorotolyl Protecting Group in the Synthesis of Pure Z and E Isomers of 4-Hydroxytamoxifen -1-(4-hydroxyphenyl)-2-phenyl-1-butene>

The perfluorotolyl protecting group has been used in the synthesis of pure Z and E isomers of 4-hydroxytamoxifen (4a), a potent metabolite of the anticancer drug, tamoxifen (1a). 4-(Perfluorotolyloxy)phenyl magnesium bromide underwent addition to the carbonyl group of the easily prepared versatile ketone, 1--2-phenyl-1-butanone (7), without affecting the chloroethoxy group.Acid catalysed dehydration of the resulting carbinol gave a 1:1 mixture of isomeric ethers, (6a) and (6b), that were easily separated by chromatography and respectively converted to the Z (4a) and E (4b) isomers of 4-hydroxytamoxifen.The property of the perfluorotolyl function in enabling the separation of geometrical isomers is attributed to a combination of its lipophilicity and electron withdrawal.