77415-40-8

Upstream product

• 1073-67-2 4-vinylbenzyl chloride 
• 64-19-7 acetic acid 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 52944-34-0 1-chloro-4-propylbenzene 
• 6285-05-8 4'-chloropropiophenone 
• 104-88-1 4-chlorobenzaldehyde 
• 546-67-8 lead(IV) tetraacetate 
• 13086-93-6 (acetyloxy)(4-chlorophenyl)methyl acetate 

Downstream Products

• 1019940-85-2 (S)-1-(4-chlorophenyl)propyl acetate 
• 110611-21-7 (R)-1-(4-chlorophenyl)-1-propanol 
• 444729-09-3 (R)-(+)-1-(4'-chlorophenyl)propyl acetate 

Relevant academic research and scientific papers

Photoredox-Catalyzed Benzylic Esterification via Radical-Polar Crossover

Photoredox-catalyzed C-O bond formation reactions are reported. The decarboxylative esterification reaction allows the conversion of a variety of arylacetic acids into the corresponding benzyl carboxylates. Furthermore, the use of (diacetoxyiodo)benzene allows the conversion of the benzylic C-H bond through hydrogen atom transfer. The reactions were applied to the divergent transformation of pharmaceuticals via decarboxylative or C-H esterification reactions.

Alkene Oxyalkylation Enabled by Merging Rhenium Catalysis with Hypervalent Iodine(III) Reagents via Decarboxylation

Rhenium-catalyzed oxyalkylation of alkenes is described, where hypervalent iodine(III) reagents derived from widely occurring aliphatic carboxylic acids were used as, for the first time, not only an oxygenation source but also an alkylation source via decarboxylation. The reaction also features a wide substrate scope, totally regiospecific difunctionalization, mild reaction conditions, and ready availability of both substrates. Mechanistic studies revealed a decarboxylation/radical-addition/cation-trapping cascade operating in the reaction.

Sonochemical reactions of lead tetraacetate with 4-substituted styrenes

A good linear free energy relationship was observed between the radical reactivity of the sonochemical reactions of 4-substituted styrenes with lead tetraacetate and the vapor pressure of the styrenes, indicating a probable control of the process by an intra-bubble activation.

The chemistry of acylals. Part I. The reactivity of acylals towards Grignard and organolithium reagents

Aldehyde acylals have been prepared and reacted with Grignard and alkyllithium reagents. Acylals from formaldehyde furnished complex reaction mixtures when reacted with both reagents. Acylals of other aldehydes gave reaction mixtures that consisted mainly of an ester, generated by replacing one of the carboxy groups with the organic part of the organometallic reagent, and regenerated aldehyde. The esters were formed in the highest yields. Yields above 90% were experienced when the acylals were reacted with Grignard reagents under Barbier conditions.

Novel Carboxymethylation of Styrene Derivatives by Mn(3+)-Mediated Electrooxidation

Anodic oxidation in a mixed solvent of acetic acid and acetic anhydride containing a variety of styrene derivatives, small amounts of Mn(OAc)2*4H2O and Cu(OAc)2*H2O brought about a facile carboxymethylation to give the corresponding γ-butyrolactones as the main products in good yields.

CARBON-CARBON BOND FORMATION USING MANGANESE(III) ACETATE AS AN ELECTROCHEMICAL MEDIATOR

Anodic oxidation in a solution containing a variety of olefins and a small amount of Mn(OAc)2*4H2O brought about Mn+3-mediated carbon-carbon bond formation, such as efficient carboxymethylation of styrene derivatives to the corresponding γ-aryl-γ-butyrolactones, and selective coupling of active methylene compounds with non-activated monoolefins, unconjugated dienes or 5-arylpent-1-enes.