77507-53-0Relevant academic research and scientific papers
Construction of pyrrole- and indole-fused CF3-piperazine derivatives
Tian, Yu-Ting,Zong, Yu-Wei,Nie, Jing,Zhang, Fa-Guang,Ma, Jun-An
, (2019/09/03)
A series of pyrrole- and indole-fused trifluoromethyl-functionalized piperazine derivatives were constructed in moderate to good yields with excellent chemoselectivities via a Pictet-Spengler reaction under mild and operationally simple conditions. The synthetic utility of this protocol was further extended by the facile preparation of indole-fused CF3-1,4-diazocane and enantioenriched CF3-piperazines via a vinylogous Pictet-Spengler reaction and an asymmetric Pictet-Spengler reaction, respectively.
One-pot synthesis of 1-phenylsulfonyl-2-aroylindoles
Dhayalan, Vasudevan,Panchapakesan, Ganapathy,Mohanakrishnan, Arasambattu K.
, p. 402 - 411 (2011/11/13)
Interaction of phenylsulfonyl-2-aminobenzaldehyde with 2-bromo-1- phenylethanones in the presence of K2CO3 followed by acid-catalyzed dehydration led to the formation of 1-phenylsulfonyl-2-aroylindoles.Copyright Taylor & Francis Group, LLC.
A direct lithiation route to 2-acyl-1-(phenylsulfonyl)indoles
Jiang, Jun,Gribble, Gordon W.
, p. 2035 - 2040 (2007/10/03)
2-Acyl-1-(phenylsulfonyl)indoles (3, 7-9) are prepared in 75-84% yield from 1-(phenylsulfonyl)indoles (1, 5) in one operation by treatment of the latter with s-butyllithium followed by inverse quenching of the C-2 lithioindoles with carboxylic acid anhydr
