77548-27-7

Upstream product

• 1896-62-4 (E)-benzalacetone 
• 105-53-3 diethyl malonate 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 685-87-0 Diethyl 2-bromomalonate 
• 5292-53-5 diethyl benzalmalonate 
• 67-64-1 acetone 

Downstream Products

• 4354-90-9 (3-oxo-1-phenyl-butyl)-malonic acid 
• 1345614-45-0 C₁₇H₂₂O₆ 
• 1345614-40-5 diethyl 2-hydroxy-2-(3-oxo-1-phenylbutyl)malonate 
• 137654-28-5 (3S)-ethyl 5-oxo-3-phenylhexanoate 
• 859196-06-8 (3-oxo-1-phenyl-butyl)-malonic acid monoethyl ester 
• 6049-47-4 5-oxo-3-phenylhexanoic acid 

Relevant academic research and scientific papers

Phase-transfer catalyzed Michael addition reaction using a new C 2-symmetric quaternary ammonium salt derived from l-proline

A new C2-symmetric quaternary ammonium salt easily prepared from l-proline, was developed and used as an efficient phase-transfer catalyst (PTC) in Michael addition reaction of various active methylene compounds to aromatic enones. Malonate est

Highly efficient 1,4-addition of 1,3-diesters to conjugated enones by In/TMSCl

Organoindium reagents derived from indium and diethyl bromomalonates were added to a wide range of conjugated enones in a 1,4-fashion in the presence of TMSCl under mild conditions, and corresponding oxo-1,3-diesters were obtained in good to excellent yields.

Amino acid catalyzed direct asymmetric aldol reactions: A bioorganic approach to catalytic asymmetric carbon-carbon bond-forming reactions

Direct asymmetric catalytic aldol reactions have been successfully performed using aldehydes and unmodified ketones together with commercially available chiral cyclic secondary amines as catalysts. Structure-based catalyst screening identified L-proline a

Asymmetric induction in Michael addition reactions mediated by C2-symmetric aluminate

The C2-symmetric chiral amino-diol, (1R, 5R)-3-aza-3- benzyl-1,5-diphenylpentan-1,5-diol (1) is available readily from the reaction of benzylamine with a twofold excess of enantiopure R(+)-styrene epoxide. We have recently shown that the titano

Michael reaction in the solid state under microwave irradiations

The Michael reaction of α,β-ethylenic ketones with nitroalkane, diethylmalonate, acetonitrile and acetylacetone in presence of alumina and without any solvent, under microwave irradiations proceeded very efficiently and furnished excellent yields of adducts.

A new method for the preparation of Michael adducts and cyclic enones using lithium chloride-hexamethylphosphoramide system

A new procedure using lithium chloride in hexamethylphosphoramide was found to be useful for the synthesis of Michael-type adducts and cyclic enones. Selectivity for the two products could be controlled by altering the reaction temperature employed. The urea-type solvents were also examined instead of hexamethylphosphoramide.

Process for preparing highly substituted phenyls

A process is described in which a lactone STR1 is reacted with an alkylester X1 --CH2 and an oxidizing or dehydrogenating agent to form the phenol ester STR2