78037-12-4

Basic information

• Product Name: (R)-3-Methyl-2-((1S,5R)-7-oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester
• Synonyms: (R)-3-Methyl-2-((1S,5R)-7-oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester
• CAS NO: 78037-12-4
• Molecular Weight: 452.51
• Mol File: 78037-12-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-3-Methyl-2-((1S,5R)-7-oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-Methyl-2-((1S,5R)-7-oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester(78037-12-4)
• EPA Substance Registry System: (R)-3-Methyl-2-((1S,5R)-7-oxo-3-phenyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid benzhydryl ester(78037-12-4)

Safety Data

• Hazardous Substances Data: 78037-12-4(Hazardous Substances Data)

Upstream product

• 51415-31-7 (2S,4S,6R)-6-Benzoylamino-3,3-dimethyl-4,7-dioxo-4λ⁴-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester 
• 65-85-0 benzoic acid 
• 75-98-9 Trimethylacetic acid 
• 551-16-6 6-Aminopenicillanic Acid 
• 51415-31-7 C₂₈H₂₆N₂O₅S 
• 98-88-4 benzoyl chloride 
• 6489-59-4 Phenyl penicillin 
• 64389-27-1 C₁₅H₁₆N₂O₅S 

Downstream Products

• 1427682-95-8 C₂₃H₂₈N₂O₆ 
• 1427682-96-9 C₂₂H₂₂N₂O₇ 
• 1427682-97-0 C₂₂H₂₂N₂O₇ 
• 1427682-98-1 C₂₂H₂₃N₃O₆ 
• 1427682-99-2 C₂₃H₂₄N₂O₇ 
• 1427683-00-8 C₂₃H₂₄N₂O₇ 
• 1427683-01-9 C₂₇H₃₀N₂O₉ 
• 1427683-02-0 C₂₇H₃₀N₂O₉ 
• 1427683-03-1 C₂₆H₂₆N₂O₆ 
• 1427683-04-2 C₂₆H₂₆N₂O₆ 
• 1427683-05-3 C₂₆H₂₉N₃O₆ 
• 1427683-06-4 C₂₆H₂₉N₃O₆ 
• 1427683-07-5 C₂₅H₂₆N₂O₇ 
• 1427683-08-6 C₂₅H₂₆N₂O₇ 

Relevant articles and documents

The new convenient synthesis of novel γ-alkylidenebutenolides from 6-aminopenicillanic acid

Butenolides have good biological activity and serve as the important unit of pharmaceutical intermediates, of which γ-alkylidenebutenolides have gained wide attention over the last past decades particularly. A simple and practical method for the synthesis of butenolide 6 and its 5-substituted analogues 7a-t via vinylogous aldol reaction from 6-aminopenicillanic acid (6-APA) with the ratio of Z/E isomers between 1.1/1.0 and 1.0/0 under mild conditions in 6 steps was first reported. Besides, we also reported the methanolysis behaviors of azetidinone fused oxazoline derivatives. All the synthesized γ-alkylidenebutenolides are new and are currently being evaluated for their biological activities.