78443-73-9

Usage

Uses

Used in Organic Synthesis:
2-(benzyloxy)-4,6-dichlorobenzaldehyde is utilized as an intermediate in organic synthesis for the creation of a variety of organic compounds. Its versatile chemical structure allows for the development of new molecules with potential applications across different industries.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-(benzyloxy)-4,6-dichlorobenzaldehyde serves as a key intermediate for the synthesis of biologically active molecules and new drugs. Its potential biological and pharmacological activities make it a promising candidate for drug development, contributing to the advancement of treatments for various diseases and conditions.
Used in the Development of New Drugs:
2-(benzyloxy)-4,6-dichlorobenzaldehyde's role in the development of new drugs is significant due to its ability to be modified and incorporated into various molecular structures. This flexibility enables researchers to explore its potential in treating a wide range of medical conditions, thereby expanding the scope of available therapeutic options.
Used in Biologically Active Molecule Development:
2-(benzyloxy)-4,6-dichlorobenzaldehyde is also important in the development of biologically active molecules. Its unique properties allow it to interact with biological systems, making it a valuable component in the creation of molecules that can have a significant impact on human health and medicine.

Upstream product

• 100-39-0 benzyl bromide 
• 78443-72-8 4,6-dichlorosalicylaldehyde 

Downstream Products

• 78443-79-5 (E)-7-<2,4-dichloro-6-(phenylmethoxy)phenyl>-3,5-dihydroxy-6-heptenoic acid 
• 78443-77-3 methyl (E)-7-<2,4-dichloro-6-(phenylmethoxy)phenyl>-5-hydroxy-3-oxo-6-heptenoate 
• 78443-78-4 methyl (E)-7-<2,4-dichloro-6-(phenylmethoxy)phenyl>-3,5-dihydroxy-6-heptenoate 
• 78443-80-8 (E)-6-<2-<2,4-dichloro-6-(phenylmethoxy)phenyl>ethenyl>-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one 
• 78443-80-8 (E)-6-<2-<2,4-dichloro-6-(phenylmethoxy)phenyl>ethenyl>-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one 
• 78444-23-2 (+)-trans-(E)-6-<2-<2,4-dichloro-6-(phenylmethoxy)phenyl>ethyl>-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one 
• 1461-25-2 tetra-n-butyltin(IV) 
• 78443-74-0 (E)-3-<2,4-dichloro-6-(phenylmethoxy)phenyl>-2-propenal 

Relevant academic research and scientific papers

Choline Hydroxide as a Versatile Medium for Catalyst-Free O-Functionalization of Phenols

A versatile synthetic protocol for benzyl phenyl ether preparation via O-alkylation of phenolic oxygen with readily available benzyl derivatives was demonstrated. The newly designed procedure was carried out using an eco-friendly medium, room-temperature ionic liquid (choline hydroxide), under metal- and base-catalyst-free aerobic conditions. The reaction platform was also successfully applied to phenol protection strategy.

Substituted pyranone inhibitors of cholesterol synthesis

The methyl, ethyl, n-propy, 2-(acetylamino)ethyl, or 1-(2,3-dihydroxy)propyl ester of E-(3R,5S)-7-(4'-fluoro-3,3',5-trimethyl[1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic acid of structural formula: STR1 are HMG-CoA reductase inhibitors useful in the treatment of conditions associated with hypercholesterolemia.

Substituted pyranone inhibitors of cholesterol synthesis

6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

SUBSTITUTED PYRANONE INHIBITORS OF CHOLESTEROL SYNTHESIS

6-Phenyl-, phenylalkyl-and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductas

Cis/trans isomerization of 6-(substituted-aryl-ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-ones

Biologically inactive cis-6-(substituted-arylethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-ones are isomerized to the corresponding anti-hypercholesterolemic trans-isomers by heating in the presence of a heavy metal salt.