78443-77-3

Basic information

• Product Name: methyl (E)-7-<2,4-dichloro-6-(phenylmethoxy)phenyl>-5-hydroxy-3-oxo-6-heptenoate
• Synonyms: methyl (E)-7-<2,4-dichloro-6-(phenylmethoxy)phenyl>-5-hydroxy-3-oxo-6-heptenoate
• CAS NO: 78443-77-3
• Molecular Weight: 423.293
• Mol File: 78443-77-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: methyl (E)-7-<2,4-dichloro-6-(phenylmethoxy)phenyl>-5-hydroxy-3-oxo-6-heptenoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (E)-7-<2,4-dichloro-6-(phenylmethoxy)phenyl>-5-hydroxy-3-oxo-6-heptenoate(78443-77-3)
• EPA Substance Registry System: methyl (E)-7-<2,4-dichloro-6-(phenylmethoxy)phenyl>-5-hydroxy-3-oxo-6-heptenoate(78443-77-3)

Safety Data

• Hazardous Substances Data: 78443-77-3(Hazardous Substances Data)

Upstream product

• 78443-73-9 2,4-dichloro-6-(phenylmethoxy)benzaldehyde 
• 78443-72-8 4,6-dichlorosalicylaldehyde 
• 100-39-0 benzyl bromide 
• 105-45-3 acetoacetic acid methyl ester 
• 78443-74-0 (E)-3-<2,4-dichloro-6-(phenylmethoxy)phenyl>-2-propenal 

Downstream Products

• 78444-23-2 (+)-trans-(E)-6-<2-<2,4-dichloro-6-(phenylmethoxy)phenyl>ethyl>-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one 
• 78443-80-8 (E)-6-<2-<2,4-dichloro-6-(phenylmethoxy)phenyl>ethenyl>-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one 
• 78443-80-8 (E)-6-<2-<2,4-dichloro-6-(phenylmethoxy)phenyl>ethenyl>-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one 
• 78443-79-5 (E)-7-<2,4-dichloro-6-(phenylmethoxy)phenyl>-3,5-dihydroxy-6-heptenoic acid 
• 78443-78-4 methyl (E)-7-<2,4-dichloro-6-(phenylmethoxy)phenyl>-3,5-dihydroxy-6-heptenoate 

Relevant articles and documents

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 2. Structural modification of 7-(substituted aryl)-3,5-dihydroxy-6-heptenoic acids and their lactone derivatives

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Substituted pyranone inhibitors of cholesterol synthesis

6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

Cis/trans isomerization of 6-(substituted-aryl-ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-ones

Biologically inactive cis-6-(substituted-arylethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-ones are isomerized to the corresponding anti-hypercholesterolemic trans-isomers by heating in the presence of a heavy metal salt.