78443-74-0

Basic information

• Product Name: (E)-3-<2,4-dichloro-6-(phenylmethoxy)phenyl>-2-propenal
• Synonyms: (E)-3-<2,4-dichloro-6-(phenylmethoxy)phenyl>-2-propenal
• CAS NO: 78443-74-0
• Molecular Weight: 307.176
• Mol File: 78443-74-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (E)-3-<2,4-dichloro-6-(phenylmethoxy)phenyl>-2-propenal(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-<2,4-dichloro-6-(phenylmethoxy)phenyl>-2-propenal(78443-74-0)
• EPA Substance Registry System: (E)-3-<2,4-dichloro-6-(phenylmethoxy)phenyl>-2-propenal(78443-74-0)

Safety Data

• Hazardous Substances Data: 78443-74-0(Hazardous Substances Data)

Upstream product

• 6153-56-6 oxalic acid dihydrate 
• 1193-93-7 ethylidenecyclohexylamine 
• 78443-73-9 2,4-dichloro-6-(phenylmethoxy)benzaldehyde 
• 78443-72-8 4,6-dichlorosalicylaldehyde 
• 100-39-0 benzyl bromide 
• 144-55-8 sodium hydrogencarbonate 
• 20420-43-3 (E)-2-ethoxyvinyltributyltin 

Downstream Products

• 78444-23-2 (+)-trans-(E)-6-<2-<2,4-dichloro-6-(phenylmethoxy)phenyl>ethyl>-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one 
• 78443-80-8 (E)-6-<2-<2,4-dichloro-6-(phenylmethoxy)phenyl>ethenyl>-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one 
• 78443-80-8 (E)-6-<2-<2,4-dichloro-6-(phenylmethoxy)phenyl>ethenyl>-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one 
• 78443-78-4 methyl (E)-7-<2,4-dichloro-6-(phenylmethoxy)phenyl>-3,5-dihydroxy-6-heptenoate 
• 78443-79-5 (E)-7-<2,4-dichloro-6-(phenylmethoxy)phenyl>-3,5-dihydroxy-6-heptenoic acid 
• 78443-77-3 methyl (E)-7-<2,4-dichloro-6-(phenylmethoxy)phenyl>-5-hydroxy-3-oxo-6-heptenoate 

Relevant articles and documents

Substituted pyranone inhibitors of cholesterol synthesis

The methyl, ethyl, n-propy, 2-(acetylamino)ethyl, or 1-(2,3-dihydroxy)propyl ester of E-(3R,5S)-7-(4'-fluoro-3,3',5-trimethyl[1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic acid of structural formula: STR1 are HMG-CoA reductase inhibitors useful in the treatment of conditions associated with hypercholesterolemia.

Substituted pyranone inhibitors of cholesterol synthesis

6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

Cis/trans isomerization of 6-(substituted-aryl-ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-ones

Biologically inactive cis-6-(substituted-arylethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-ones are isomerized to the corresponding anti-hypercholesterolemic trans-isomers by heating in the presence of a heavy metal salt.