785027-07-8Relevant academic research and scientific papers
Design, synthesis and structure-activity relationships of benzoxazinone-based factor Xa inhibitors
Huang, Wenrong,Zhang, Penglie,Zuckett, Jingmei F.,Wang, Lingyan,Woolfrey, John,Song, Yonghong,Jia, Zhaozhong J.,Clizbe, Lane A.,Su, Ting,Tran, Katherine,Huang, Brian,Wong, Paul,Sinha, Uma,Park, Gary,Reed, Andrea,Malinowski, John,Hollenbach, Stanley J.,Scarborough, Robert M.,Zhu, Bing-Yan
, p. 561 - 566 (2007/10/03)
A series of benzoxazinone derivatives was designed and synthesized as factor Xa inhibitors. We demonstrated that the naphthyl moiety in the aniline-based compounds 1 and 2 can be replaced with benzene-fused heterobicycles and biaryls to give factor Xa inh
The discovery of YM-60828: a potent, selective and orally-bioavailable factor Xa inhibitor.
Hirayama, Fukushi,Koshio, Hiroyuki,Katayama, Naoko,Kurihara, Hiroyuki,Taniuchi, Yuta,Sato, Kazuo,Hisamichi, Nami,Sakai-Moritani, Yumiko,Kawasaki, Tomihisa,Matsumoto, Yuzo,Yanagisawa, Isao
, p. 1509 - 1523 (2007/10/03)
Since Factor Xa (FXa) is well known to play a central role in thrombosis and hemostasis, inhibition of FXa is an attractive target for antithrombotic strategies. As a part of our investigation of a non-peptide, orally available FXa inhibitor, we found tha
