79491-44-4

Usage

Uses

Used in Pharmaceutical Industry:
2,3-Dimethoxy-6-nitropyridine is utilized as a key intermediate in the synthesis of various medications. Its reactivity and structural properties make it suitable for the development of new pharmaceutical compounds, contributing to the advancement of drug discovery and therapeutic applications.
Used in Agrochemical Manufacturing:
In the agrochemical sector, 2,3-Dimethoxy-6-nitropyridine is employed as a precursor in the production of pesticides and other agrochemicals. Its chemical properties allow for the creation of effective compounds designed to protect crops and enhance agricultural productivity.
Used in Specialty Chemicals Production:
2,3-Dimethoxy-6-nitropyridine also finds application in the manufacturing of specialty chemicals, where its unique characteristics are harnessed to produce high-quality products for specific industrial applications.

Upstream product

• 67-56-1 methanol 
• 76066-07-4 2-bromo-3-methoxy-6-nitropyridine 
• 115170-07-5 2-Iod-3-methoxy-6-nitropyridin 
• 124-41-4 sodium methylate 
• 24100-18-3 2-bromo-3-methoxypyridine 
• 115170-06-4 2-Iod-3-methoxy-6-nitropyridin-1-oxid 
• 115927-86-1 2-iodo-3-methoxypyridine 1-oxide 
• 93560-55-5 2-iodo-3-methoxy-pyridine 
• 40263-57-8 2-iodo-3-hydroxypyridine 

Downstream Products

• 127980-46-5 5,6-dimethoxypyridin-2-amine 

Relevant academic research and scientific papers

TRIAZOLE COMPOUNDS AS LIPOXYGENASE INHIBITORS

There is provided compounds of formula (I) wherein W is an optionally substituted aryl or heteroaryl group, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15- lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.

PYRAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION

There is provided compounds of formula (I), wherein R1, R2, X1, X2 and n have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15-lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.

Notiz zur chemischen Reaktivitaet von hydroxylierten Pyridinen

Ueber mehrere Schritte werden Maltol in 3,4-Dimethoxy-2-methylpyridin (2b) und Kojisaeure in 3-Brom-4-hydroxy-5-methoxypyridin ueberfuehrt.Die Bromierung von 3,3'-Dihydroxy-2,2'-bipyridin (6) liefert ein Gemisch von Monobrom-, Dibrom-, Tribrom- und Tetrabromverbindungen 7a bis 7g, bei denen die 6-Bromderivate vorherrschen.Aehnliche Substitutionsmuster werden bei der Nitrierung von 6 erhalten, wobei die Verbindungen 7h - 7j erhalten werden.Ausgehend von 2-Iod-3-methoxypyridin (8) lassen sich die Substitutionsprodukte 10 bis 15 darstellen.Als besonders interessant erweist sich 3-Methoxy-2-iod-6-nitropyridin (11), das sich zu dem 3,3',6,6'-Tetrahydroxy-2,2'-bipyridin (16d) umwandeln laesst, einen Isomeren des Naturstoffs Orellin.

Synthetic Uses of the Sequential Ring Positional Reactivity in Pyridin-3-ol and Derivatives

A series of ring-substituted pyridin-3-ols has been prepared.The key to the scheme is the introduction of a bromo group to a specific ring position as a temporary blocking agent.As well as hydrogenolysis of the bromo function, nucleophilic displacement has also been investigated.