79623-15-7

Basic information

• Product Name: 2-(4-methoxyphenyl)-tetrahydrofuran
• Synonyms: 2-(4-methoxyphenyl)-tetrahydrofuran;Tetrahydro-2-(4-methoxyphenyl)furan
• CAS NO: 79623-15-7
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.22766
• Mol File: 79623-15-7.mol
• Article Data: 35

Chemical Properties

• Melting Point: 61-63 °C
• Boiling Point: 140 °C(Press: 0.2 Torr)
• Appearance: /
• Density: 1.061±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-(4-methoxyphenyl)-tetrahydrofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-tetrahydrofuran(79623-15-7)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-tetrahydrofuran(79623-15-7)

Safety Data

• Hazardous Substances Data: 79623-15-7(Hazardous Substances Data)

Usage

General Description

2-(4-methoxyphenyl)-tetrahydrofuran is a chemical compound that consists of a tetrahydrofuran ring with a methoxyphenyl group attached to the second carbon atom. It is commonly used as a building block in the synthesis of various pharmaceuticals and organic compounds. This chemical is known for its ability to act as a solvent for organic reactions and as a reagent in various chemical processes. Additionally, it possesses an aromatic ring with a methoxy substituent, making it potentially useful in medicinal chemistry for its ability to interact with biological targets. Overall, 2-(4-methoxyphenyl)-tetrahydrofuran is a versatile and potentially useful chemical compound with a range of applications in the field of chemistry.

Upstream product

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• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 1191-99-7 2,3-dihydro-2H-furan 
• 66107-29-7 4-methoxyphenyl triflate 
• 1708-29-8 2,5-dihydrofuran 
• 5023-67-6 4-methoxybenzyl phenyl sulfide 

Downstream Products

• 1380436-41-8 (S)-2-(4’-methoxyphenyl)tetrahydrofuran 

Relevant articles and documents

An Intramolecular Iodine-Catalyzed C(sp3)?H Oxidation as a Versatile Tool for the Synthesis of Tetrahydrofurans

The formation of ubiquitous occurring tetrahydrofuran patterns has been extensively investigated in the 1960s as it was one of the first examples of a non-directed remote C?H activation. These approaches suffer from the use of toxic transition metals in overstoichiometric amounts. An attractive metal-free solution for transforming carbon-hydrogen bonds into carbon-oxygen bonds lies in applying economically and ecologically favorable iodine reagents. The presented method involves an intertwined catalytic cycle of a radical chain reaction and an iodine(I/III) redox couple by selectively activating a remote C(sp3)?H bond under visible-light irradiation. The reaction proceeds under mild reaction conditions, is operationally simple and tolerates many functional groups giving fast and easy access to different substituted tetrahydrofurans.

Heterocyclization involving benzylic C(sp3)-H functionalization enabled by visible light photoredox catalysis

A general and efficient method for heterocyclization involving benzylic C(sp3)-H functionalization enabled by visible light photoredox catalysis to access a wide range of structurally diverse oxygen as well as nitrogen heterocycles up to a gram scale is reported. The potential application of this new methodology is demonstrated by the total synthesis of (-)-codonopsinine and (+)-centrolobine. Herein it is proposed that selectfluor, unlike a fluorinating reagent, acts as an oxidative quencher and a hydrogen radical acceptor.

The Combination of Benzaldehyde and Nickel-Catalyzed Photoredox C(sp3)?H Alkylation/Arylation

Herein we report a highly selective photoredox C(sp3)?H alkylation/arylation of ethers through the combination of a photo-organocatalyst (benzaldehyde) and a transition-metal catalyst (nickel). This method provides a simple and general strategy for the C(sp3)?H alkylation/arylation of ethers. A selective late-stage modification of (?)-ambroxide has also been conducted to demonstrate the applicability of the method.