79754-55-5

Upstream product

• 141-82-2 malonic acid 
• 79754-53-3 p-methoxy-α-p-methoxyphenylcinnamaldehyde 
• 6443-74-9 p-methoxy-α-p-methoxyphenylcinnamonitrile 
• 20498-71-9 1,2-bis(4-methoxyphenyl)ethan-1-ol 
• 123-11-5 4-methoxy-benzaldehyde 
• 104-47-2 p-methoxybenzylnitrile 

Downstream Products

• 79813-32-4 (+/-)-di-O-methylsequirin D 
• 79813-33-5 (+/-)-sequirin D 
• 79754-58-8 7-hydroxy-4-p-hydroxybenzyl-3,4-dihydronaphthalen-1(2H)-one 
• 79754-54-4 7-hydroxy-4-p-hydroxybenzyl-1,2,3,4-tetrahydro-1-naphthol 
• 79754-56-6 7-methoxy-4-p-methoxybenzyl-3,4-dihydronaphthalen-1(2H)-one 
• 79754-57-7 7-methoxy-4-p-methoxybenzyl-1,2,3,4-tetrahydro-1-naphthol 
• 79754-48-6 4,5-bis-(p-methoxyphenyl)pentanoic acid 

Relevant academic research and scientific papers

Synthesis of 5-p-Hydroxybenzyl-5,6-dihydro-2-naphthol, (+/-)-Sequirin D

A high-yield six-step synthesis of sequirin D (1a), a naturally occurring norlignan, is described.Michael addition of deoxyanisoin (2) to acrylonitrile gives a ketonitrile (3), which on Wolff-Kishner reduction is reduced and hydrolysed in situ to 4,5-bis-