79942-52-2Relevant academic research and scientific papers
Synthesis of phenanthridines by I2-mediated sp3C-H amination
Chang, Junbiao,Fang, Benyao,Hou, Jiao,Tian, Jinyue,Yu, Wenquan
, p. 3312 - 3323 (2020/05/14)
An I2-mediated synthesis of phenanthridinesviaintramolecular sp3C-H amination of readily accessible aniline precursors is reported. The present synthetic process is straightforward and applicable to a broad variety of unprotected ani
Iron-Catalyzed Aerobic Dehydrogenative Kinetic Resolution of Cyclic Secondary Amines
Lu, Ran,Cao, Liya,Guan, Honghao,Liu, Lei
, p. 6318 - 6324 (2019/05/09)
A nonenzymatic iron-catalyzed dehydrogenative kinetic resolution of cyclic secondary amines using air as an oxidant has been reported. The economical and practical method is applicable to a series of cyclic benzylic amines, including 5,6-dihydrophenanthridines and 1,2-dihydroquinolines, with diverse functional groups at the α position in high yields with excellent enantioselectivities. The direct dehydrogenative kinetic resolution of advanced intermediates of bioactive molecules that are difficult to access using existing catalytic asymmetric synthetic strategy was also demonstrated.
Visible-light-induced tandem radical addition-cyclization of 2-aryl phenyl isocyanides catalysed by recyclable covalent organic frameworks
Liu, Shuyang,Pan, Wenna,Wu, Songxiao,Bu, Xiubin,Xin, Shigang,Yu, Jipan,Xu, Hao,Yang, Xiaobo
, p. 2905 - 2910 (2019/06/17)
A visible-light-induced tandem radical addition-cyclization sequence via 2-aryl phenyl isocyanides as the starting material and two-dimensional covalent organic frameworks (2D-COFs) as the photocatalyst was developed, delivering multifarious 6-substituted phenanthridines in high yields. Benefitting from the utilization of a heterogeneous photocatalyst, this protocol features easy catalyst separation and excellent recyclability. A negligible loss of the catalytic activity was observed after multiple runs. High practicability of this protocol was further demonstrated by continuous flow experiments.
Metal-free photocatalyzed cross coupling of aryl (heteroaryl) bromides with isonitriles
Li, Xiangguang,Liang, Deqiang,Huang, Wenzhong,Sun, Huanli,Wang, Lvsu,Ren, Mengran,Wang, Baoling,Ma, Yinhai
, p. 7094 - 7099 (2017/11/13)
A visible-light-catalyzed synthesis of 6-aryl substituted phenanthridines from aryl bromides and 2-isocyanobiphenyls at room temperature has been discovered. This metal-free cross-coupling reaction offers rapid and sustainable access to a series of struct
Preparation of Substituted Phenanthridines from the Coupling of Aryldiazonium Salts with Nitriles: A Metal Free Approach
Ramanathan, Mani,Liu, Shiuh-Tzung
, p. 5329 - 5336 (2015/05/27)
A transition metal free approach for the synthesis of substituted phenanthridines from the coupling reaction of aryldiazonium tetrafluoroborates with nitriles has been developed. This operationally simple protocol proceeds through a substitution of aryldiazonium with nitriles followed by an intramolecular arylation to provide the corresponding phenanthridines in moderate to excellent yields. (Chemical Equation Presented).
Synthesis of phenanthridine derivatives via cascade annulation of diaryliodonium salts and nitriles
Li, Jian,Wang, Hongni,Sun, Jiangtao,Yang, Yang,Liu, Li
, p. 7904 - 7908 (2014/12/12)
A cascade coupling reaction toward a variety of phenanthridine derivatives has been developed. This cascade transformation proceeds via the copper-catalyzed coupling reaction of diaryliodonium salts and nitriles, and undergoes cyclization into the phenanthridine core.
Synthesis of 6-substituted phenanthridines by metal-free, visible-light induced aerobic oxidative cyclization of 2-isocyanobiphenyls with hydrazines
Xiao, Tiebo,Li, Linyong,Lin, Guoliang,Wang, Qile,Zhang, Ping,Mao, Zong-Wan,Zhou, Lei
supporting information, p. 2418 - 2421 (2014/05/06)
Irradiation of hydrazines with visible-light in the presence of organic dye eosin B generates various types of functional radicals, which are trapped by 2-isocyanobiphenyls to give 6-substituted phenanthridines. the Partner Organisations 2014.
Transition-metal-free, visible-light induced cyclization of arylsulfonyl chlorides with 2-isocyanobiphenyls to produce phenanthridines
Gu, Lijun,Jin, Cheng,Liu, Jiyan,Ding, Hongyan,Fan, Baomin
supporting information, p. 4643 - 4645 (2014/05/06)
6-Aryl substituted phenanthridines were synthesized via a visible-light-catalyzed cyclization of 2-isocyanobiphenyls with arylsulfonyl chlorides under oxidant-free and transition-metal-free conditions. This transformation represents an efficient and attractive synthetic utilization of arylsulfonyl chlorides. the Partner Organisations 2014.
Efficient synthesis of phenanthridines using Hendrickson reagent initiated cascade reaction under mild conditions
Xi, Jie,Dong, Qing-Li,Liu, Guan-Sai,Wang, Shaozhong,Chen, Lin,Yao, Zhu-Jun
supporting information; experimental part, p. 1674 - 1678 (2010/08/20)
A number of variously substituted phenanthridines have been synthesized using the newly developed methodology under mild conditions. The Hendrickson reagent initiated cascade annulation, which is composed of a mild conversion of stable amide precursor to highly reactive imido-carbonium intermediate and a subsequent intramolecular Friedel-Crafts reaction, successfully served as the key method. Georg Thieme Verlag Stuttgart New York.
Trifluoroacetic acid-mediated facile construction of 6-substituted phenanthridines
Youn, So Won,Bihn, Joon Hyung
supporting information; experimental part, p. 4598 - 4601 (2009/10/11)
The trifluoroacetic acid-mediated reaction of 2-arylanilines with arylaldehydes has been developed to give a variety of 6-substituted phenanthridines. This is a very simple and convenient one-pot process for library construction.
