80213-01-0

Basic information

• Product Name: 1-Benzyl-4-hydroxypiperidine
• Synonyms: 4-Piperidinol,1-benzoyl- (9CI); 1-Benzoyl-4-piperidinol; N-Benzoyl-4-hydroxypiperidine
• CAS NO: 80213-01-0
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.25
• Mol File: 80213-01-0.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Benzyl-4-hydroxypiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-4-hydroxypiperidine(80213-01-0)
• EPA Substance Registry System: 1-Benzyl-4-hydroxypiperidine(80213-01-0)

Safety Data

• Hazardous Substances Data: 80213-01-0(Hazardous Substances Data)

Upstream product

• 5382-16-1 4-HYDROXYPIPERIDINE 
• 65-85-0 benzoic acid 
• 24686-78-0 1-Benzoyl-4-piperidone 
• 621-84-1 O-benzyl carbamate 
• 98-88-4 benzoyl chloride 
• 100-52-7 benzaldehyde 
• 532-28-5 (RS)-mandelonitrile 
• 776-75-0 N-benzoylpiperidine 
• 613-90-1 benzoyl cyanide 

Downstream Products

• 1282036-70-7 (4-dodecylpiperidin-1-yl)(phenyl)methanone 
• 24152-44-1 (4-butylpiperidin-1-yl)(phenyl)methanone 
• 122374-26-9 1-Benzoyl-4-bromopiperidine 
• 24152-43-0 phenyl(4-propylpiperidin-1-yl)methanone 
• 90670-04-5 (4-chloropiperidin-1-yl)(phenyl)methanone 
• 1439367-23-3 (2R,3S)-3-hydroxy-2-[({[1-(phenylcarbonyl)piperidin-4-yl]oxy}carbonyl)amino]-butanoic acid 
• 1439366-57-0 (1-benzoyl-4-piperidyl) N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]-carbamate 
• 24686-78-0 1-Benzoyl-4-piperidone 
• 1005340-89-5 1-benzoyl-4-(oxiran-2-ylmethoxy)piperidine 
• 1005340-88-4 3-[(1-benzoylpiperidin-4-yl)oxy]propanenitrile 
• 1005340-90-8 1-benzoyl-4-(prop-2-ynyloxy)piperidine 
• 1005340-87-3 1-benzoylpiperidin-4-yl acetate 
• 85387-32-2 acetoacetic acid-N-benzoyl-4-piperidinyl ester 

Relevant articles and documents

Photoredox Polyfluoroarylation of Alkyl Halides via Halogen Atom Transfer

Polyfluoroarene moieties are of interest in medicinal chemistry, agrochemicals, and material sciences. Herein, we present the first polyfluoroarylation of unactivated alkyl halides via a halogen atom transfer process. This method converts primary, secondary, and tertiary alkyl halides into the respective polyfluoroaryl compounds in good yields in the presence of amide, carbamate, ester, aromatic, and sulfonamide moieties, including derivatives of complex bioactive molecules. Mechanistic work revealed that this transformation proceeds through an alkyl radical generated after the halogen atom transfer.

Stereoselective direct reductive amination of ketones with electron-deficient amines using Re2O7/NaPF6 catalyst

The first example of direct reductive amination (DRA) of ketones with electron-deficient amines (EDA) such as Cbz-, Boc-, EtOCO-, Fmoc-, Bz-, ArSO2-, etc. protected amines have been achieved using catalytic Re2O7/NaPF6. Excellent chemoselectivities as well as diastereoselectivity (for 2-alkyl cyclohexanones) were obtained. The Royal Society of Chemistry 2013.

Highly chemoselective metal-free reduction of tertiary amides

This communication describes the chemoselective metal-free reduction of tertiary amides to the corresponding amines. Hantzsch ester is used as a mild reducing agent for the reduction of trifluoromethanesulfonic anhydride activated amides providing the tertiary amines with high functional group tolerance. Copyright