81111-46-8Relevant academic research and scientific papers
Method for preparing 2-(phenylsulfinyl)phenol compound through multi-component reaction
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Paragraph 0017; 0018, (2019/08/12)
The invention discloses a method for preparing a 2-(phenylsulfinyl)phenol compound through a multi-component reaction. The preparation method comprises the following steps: fully reacting a halogenated benzene compound shown as a formula (I), sulfur dioxi
Methyl sulfinates as electrophiles in friedel-crafts reactions. Synthesis of aryl sulfoxides
Yuste, Francisco,Hernandez Linares, Angelica,Mastranzo, Virginia M.,Ortiz, Benjamin,Sanchez-Obregon, Ruben,Fraile, Alberto,Garcia Ruano, Jose Luis
, p. 4635 - 4644 (2011/07/29)
The Friedel-Crafts reaction of methyl alkyl- and arylsulfinates with aromatic systems, activated by one or more electron-donating substituents (OH, OMe, NHR, NR2), provides alkyl aryl and diaryl sulfoxides under mild conditions and in moderate to good yields. The very high regioselectivity usually observed in these sulfinylation reactions is rationalized on the basis of a Wheland intermediate having a trigonal bypyramidal structure in which steric and electronic interactions are significant factors strongly destabilizing the attack to the ortho positions.
