81561-77-5

Basic information

• Product Name: 4-T-BUTYL PROPIOPHONE
• Synonyms: 4-T-BUTYL PROPIOPHONE;2-Propanone, 1-[4-(1,1-diMethylethyl)phenyl]-;1-(4-tert-butylphenyl)propan-2-one
• CAS NO: 81561-77-5
• Molecular Formula: C₁₃H₁₈O
• Molecular Weight: 190.28142
• Mol File: 81561-77-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 263.5±9.0 °C(Predicted)
• Appearance: /
• Density: 0.939±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-T-BUTYL PROPIOPHONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-T-BUTYL PROPIOPHONE(81561-77-5)
• EPA Substance Registry System: 4-T-BUTYL PROPIOPHONE(81561-77-5)

Safety Data

• Hazardous Substances Data: 81561-77-5(Hazardous Substances Data)

Usage

General Description

4-T-BUTYL PROPIOPHONE, also known as p-tert-butylpropiophenone, is a chemical compound with the molecular formula C13H18O. It is a colorless liquid with a sweet odor, and it is commonly used as a fragrance ingredient in perfumes and other cosmetic products. This chemical is also used as a flavoring agent in food products and as a precursor in the synthesis of various pharmaceuticals. Additionally, 4-T-BUTYL PROPIOPHONE is used in the production of polymer resins and as a solvent in several industrial processes. However, it is important to handle this compound with care, as it is considered to be a hazardous substance and may cause skin and eye irritation, as well as respiratory issues if inhaled.

Upstream product

• 3549-23-3 methyl 2-(4-tert-butylphenyl)acetate 
• 852815-78-2 2-(4-tert-butylphenyl)-N-methoxy-N-methylacetamide 
• 75-16-1 methylmagnesium bromide 
• 32857-63-9 4-t-butylphenylacetic acid 
• 108-24-7 acetic anhydride 
• 80-54-6 lilial 
• 58567-80-9 1-(tert-butyl)-4-propylbenzene 
• 68175-34-8 1-(tert-butyl)-4-(prop-1-en-1-yl)benzene 
• 22796-14-1 1-(tert-butyl)-4-(methylsulfonyl)benzene 
• 67-64-1 acetone 
• 3972-56-3 4-(tert-butyl)chlorobenzene 
• 7598-28-9 4-tert-butylphenyltosylate 
• 253185-03-4 tert-butylbenzene 
• 140244-80-0 (Z)-(4-tert-butylphenyl)azo tert-butyl sulfide 

Downstream Products

• 852815-79-3 ethyl 5-[4-(1,1-dimethylethyl)phenyl]-2,4-dioxopentanoate 

Relevant articles and documents

Cobalt-Catalyzed Aerobic Oxidative Cleavage of Alkyl Aldehydes: Synthesis of Ketones, Esters, Amides, and α-Ketoamides

A widely applicable approach was developed to synthesize ketones, esters, amides via the oxidative C?C bond cleavage of readily available alkyl aldehydes. Green and abundant molecular oxygen (O2) was used as the oxidant, and base metals (cobalt and copper) were used as the catalysts. This strategy can be extended to the one-pot synthesis of ketones from primary alcohols and α-ketoamides from aldehydes.

Anti-Markovnikov Oxidation of β-Alkyl Styrenes with H2O as the Terminal Oxidant

Oxygenation of alkenes is one of the most straightforward routes for the construction of carbonyl compounds. Wacker oxidation provides a broadly useful strategy to convert the mineral oil into higher value-added carbonyl chemicals. However, the conventional Wacker chemistry remains problematic, such as the poor activity for internal alkenes, the lack of anti-Markovnikov regioselectivity, and the high cost and chemical waste resulted from noble metal catalysts and stoichiometric oxidant. Here, we describe an unprecedented dehydrogenative oxygenation of β-alkyl styrenes and their derivatives with water under external-oxidant-free conditions by utilizing the synergistic effect of photocatalysis and proton-reduction catalysis that can address these challenges. This dual catalytic system possesses the single anti-Markovnikov selectivity due to the property of the visible-light-induced alkene radical cation intermediate.

DIALKYL(2-ALKOXY-6-AMINOPHENYL)PHOSPHINE, THE PREPARATION METHOD AND USE THEREOF

The present invention relates to the compound of dialkyl(2-alkoxy-6-aminophenyl)phosphine and the preparation method thereof and the application in the palladium catalyzed coupling reactions of aryl chloride and ketone. The dialkyl(2-alkoxy-6-aminophenyl)phosphine of the present invention could coordinate with the palladium catalyst to highly selectively activate the inert carbon-chlorine bond, and to catalyze direct arylation reaction in the α-position of ketones to produce corresponding coupling compounds. The preparation method of the present invention is a simple one-step method which produces the air-stable dialkyl(2-alkoxy-6-aminophenyl)phosphine. Compared with the synthetic routes of ligands to be used in the activation of carbon-chlorine bonds in the prior arts, the preparation method of the present invention has the advantages of short route and easy operation.