75286-46-3

Upstream product

• 81638-86-0 (S)-2-((S)-2-amino-3-phenylpropanamido)-4-methylpentanamide hydrochloride 
• 81638-93-9 O-(N-t-butyloxycarbonylglycylglycyl)-2-pyridylmethylketoxime 
• 4530-20-5 BOC-glycine 
• 687-51-4 H-L-Leu-NH₂ 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 31972-52-8 Boc-Gly-Gly-OH 
• 74257-73-1 tert-butyl ((S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate 
• 81638-94-0 O-(t-butyloxycarbonyl-L-phenylalanyl)-2-pyridylmethylketoxime 
• 82948-92-3 [des-tyr¹]-leucine enkephalinamide 
• 10466-61-2 (2S)-amino-4-methylpentanamide hydrochloride 
• 93200-07-8 Boc-Gly-Phe-Leu-NH₂ 

Downstream Products

• 82948-92-3 [des-tyr¹]-leucine enkephalinamide 
• 1313481-74-1 Boc-Tyr(tBu)-Gly-Gly-Phe-Leu-NH₂ 
• 81638-90-6 amide of N-t-butyloxycarbonyl-β-alanyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine 
• 81638-88-2 amide of N-t-butyloxycarbonyl-O-benzyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine 
• 217792-96-6 C₅₇H₇₃N₆O₁₃PS₂ 
• 217792-93-3 C₄₇H₇₁N₆O₁₃PS₂ 
• 217792-91-1 2,2-dimethyl-thiopropionic acid S-(2-{[4-(2-amino-2-{[({[1-(1-carbamoyl-3-methyl-butylcarbamoyl)-2-phenyl-ethylcarbamoyl]-methyl}-carbamoyl)-methyl]-carbamoyl}-ethyl)-phenoxy]-[2-(2,2-dimethyl-propionylsulfanyl)-ethoxy]-phosphoryloxy}-ethyl) ester 

Relevant academic research and scientific papers

Peptide synthesis 'in water' by a solution-phase method using water-dispersible nanoparticle Boc-amino acid

Regulatory pressure has compelled the chemical manufacturing industry to reduce the use of organic solvents in synthetic chemistry, and there is currently a strong focus on replacing these solvents with water. Here, we describe an efficient in-water solution-phase peptide synthesis method using Boc-amino acids. It is based on a coupling reaction utilizing suspended water-dispersible nanoparticle reactants. Using this method, peptides were obtained in good yield and with high purity.

Environmentally Conscious In-Water Peptide Synthesis Using Boc Strategy

Seeking a more environmentally balanced method of peptide synthesis, we are focusing on developing organic solvent-free synthetic methods using water, an environmentally friendly solvent. In current peptide synthesis, the most common building blocks are Boc- and Fmoc-protected amino acids, which are highly soluble in organic solvents. We previously reported a technique for solid-phase peptide synthesis in water that utilizes Fmoc-amino acids converted to water-dispersible nanoparticles. The Boc strategy is well-known to be suitable for the industrial chemistry and green chemistry, because only gases are generated without any other by-products in the deprotection step of Boc group. Here we summarize in-water both liquid and solid-phase method using Boc-amino acids based on MW-assisted coupling reaction of nanosized reactants, nanoparticles and nanomicelles.

O-(N-ACYLAMINOACYL)-2-PYRIDYLMETHYLKETOXIMES AND THEIR USE IN PEPTIDE SYNTHESIS

Preparation of Leu-enkephalin, Met-enkephalin and one analog of Leu-enkephalin by using O-(N-acylaminoacyl)-2-pyridylketoximes is described.Both the side products and the unreacted active amino acid derivatives were removed by utilizing the formation of a copper complex with 2-pyridylmethylketoxime.