82-42-8Relevant articles and documents
Anti HIV-1 agents 7. Discovery of 1-hydroxy-4-chloro-9,10-anthraquinone derivatives as New HIV-1 Inhibitors in Vitro
Huang, Ning,Wang, Qin,Yang, Liu-Meng,Xu, Hui,Zheng, Yong-Tang
experimental part, p. 602 - 605 (2012/05/05)
In continuation of our program aimed at the discovery and development of anti-HIV-1 agents, six 1-hydroxy-4- chloro-9, 10-anthraquinone derivatives (3-8) were prepared and preliminarily evaluated as HIV-1 inhibitors in vitro for the first time. Compounds 4 and 6 exhibited the potent anti-HIV-1 activities with EC50 values of 9.81 and 17.90 μg/mL, and TI values of >13.58 and >11.17, respectively. It demonstrated that introduction of the alkylacyloxy or alkylsulfonyloxy group at the 1-position of 1-hydroxy-4-chloro-9,10- anthraquinone could afford the more promising and potent compound than that having arylacyloxy or arylsulfonyloxy one.
Reactions of 1-Halo-4-nitroanthraquinones with C-nucleophiles
Tabatskaya,Beregovaya
, p. 410 - 415 (2007/10/03)
1-Fluoro-4-nitroanthraquinone reacts with C-nucleophiles, yielding the corresponding fluorine replacement products. Reactions of 1-chloro-4-nitroanthraquinone with the same nucleophiles result in formation of mixtures of dechlorination and denitration pro
PHOTO-NUCLEOPHILIC SUBSTITUTION REACTION OF HALOGENOANTHRAQUINONE IN CONCENTRATED SULFURIC ACID. PHOTO-HYDROXYDEHALOGENATION
Seguchi, Kazuyoshi,Ikeyama, Hiromi
, p. 1493 - 1494 (2007/10/02)
The photo-reaction of halogen-substituted anthraquinones in sulfuric acid was studied with near UV or visible light. α-Chloro-substituted anthraquinones were photo-hydroxylated mainly to form α-hydroxyanthraquinones in fairly good yields.However, β-halogenoanthraquinones gave no dehalogenated products under the same conditions.