82208-47-7

Basic information

• Product Name: 1-METHYL-4-NITRO-1H-PYRAZOLE
• Synonyms: 1-METHYL-4-NITRO-1H-PYRAZOLE;AKOS B018701;ART-CHEM-BB B018701;1H-pyrazole, 1-methyl-4-nitro-;PYRAZOLE, 1-METHYL-4-NITRO-;STK298892;ZINC02038197
• CAS NO: 82208-47-7
• Molecular Formula: C4H5N3O2
• Molecular Weight: 127.1
• Mol File: 82208-47-7.mol
• Article Data: 58

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-METHYL-4-NITRO-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-4-NITRO-1H-PYRAZOLE(82208-47-7)
• EPA Substance Registry System: 1-METHYL-4-NITRO-1H-PYRAZOLE(82208-47-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 82208-47-7(Hazardous Substances Data)

Usage

General Description

1-Methyl-4-nitro-1H-pyrazole is a chemical compound with the molecular formula C4H5N3O2. It is a yellow crystalline powder that is commonly used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and dyes. 1-METHYL-4-NITRO-1H-PYRAZOLE is also used as an intermediate in the production of other chemicals and serves as a reactive intermediate in organic synthesis. 1-Methyl-4-nitro-1H-pyrazole is considered to be a hazardous substance and should be handled with care. It is important to follow proper safety guidelines when working with this chemical.

Upstream product

• 67-56-1 methanol 
• 77-78-1 dimethyl sulfate 
• 2075-46-9 4-nitro-1H-pyrazole 
• 39806-90-1 4-iodo-1-methyl-1H-pyrazole 
• 60-34-4 methylhydrazine 
• 181294-57-5 β-formyl-β-nitroenamine 
• 930-36-9 1-methyl-1H-pyrazole 
• 132771-14-3 1-methyl-4-nitro-5-(3-nitrobenzoyl)pyrazole 
• 92534-69-5 1-methyl-4-nitro-1H-pyrazole-5-carboxylic acid 
• 74-88-4 methyl iodide 
• 15803-02-8 4-bromo-1-methyl-1H-pyrazole 
• 34461-00-2 nitromalondialdehyde sodium salt 

Downstream Products

• 1586044-15-6 1-(1-methyl-4-nitro-1H-pyrazol-5-yl)pent-4-en-1-ol 
• 1063734-49-5 1-methyl-1H-pyrazol-4-ylamine dihydrochloride 
• 796845-64-2 tert‐butyl N‐(1‐methyl‐1H‐pyrazol‐4‐yl)carbamate 

Relevant articles and documents

C-H Amination of Nitro Azaheterocyclic Compounds by Vicarious Nucleophilic Substitution

Various nitro azaheterocyclic compounds were subjected to C H amination by vicarious nucleophilic substitution with 4H-1,2,4-triazol-4-amine (ATA). The aminated products were characterized by NMR, mass spectroscopy, and single-crystal X-ray diffraction an

Light-Triggered, Non-Centrosymmetric Self-Assembly of Aqueous Arylazopyrazoles at the Air–Water Interface and Switching of Second-Harmonic Generation

Trans-p-methoxy arylazopyrazole spontaneously forms non-centrosymmetric polar crystals, which reversibly undergo liquefaction upon photoisomerization to the cis-isomer. This liquid cis-isomer has a large electric dipole moment and is highly soluble in water (solubility up to ≈58 mM), which is remarkably higher than that of the trans-isomer (690 μM). Vis-light illumination of the aqueous cis-isomer generates macroscopically oriented, non-centrosymmetric crystals at the air–water interface. Polar crystals are also formed in sandwich glass cells (spacing, 20 μm) upon photo-induced crystallization of the liquid cis-isomer. The trans-crystals thus formed showed second harmonic generation (SHG) whose intensity is switched on/off in response to the photo-induced phase transition.

Preparation method and application of novel 6-amino-1H-pyrazolo[3,4-d]pyrimidine JAK kinase inhibitors

The present invention provides drugs used for preventing, treating and/or ameliorating autoimmune diseases (such as psoriasis, rheumatoid arthritis, inflammatory enteritis diseases, Sjogren's syndrome, Behcet's disease, multiple sclerosis and systemic lupus erythematosus). The drugs have excellent JAK kinase inhibitory activity. The present invention also provides pharmaceutically acceptable compositions including the above compounds, and methods for preparing the compounds.