82619-69-0Relevant academic research and scientific papers
Iron-Catalyzed Alkyne-Based Multicomponent Synthesis of Pyrimidines under Air
Chakraborty, Gargi,Guin, Amit Kumar,Mondal, Rakesh,Paul, Nanda D.,Sarkar, Susmita
, p. 13186 - 13197 (2021/10/01)
An iron-catalyzed sustainable, economically affordable, and eco-friendly synthetic protocol for the construction of various trisubstituted pyrimidines is described. A wide range of trisubstituted pyrimidines were prepared using a well-defined, easy to prepare, bench-stable, and phosphine-free iron catalyst featuring a redox-noninnocent tridentate arylazo pincer under comparatively mild aerobic conditions via dehydrogenative functionalization of alcohols with alkynes and amidines.
Metal-free cascade synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones
Cui, Xue,Li, Youbin,Ma, Jianting,Wang, Xuesong,Xu, Junyu,Zeng, Tingting
, p. 24247 - 24253 (2021/07/29)
A convenient metal-free synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones has been developed. In this procedure, various structural 2-aminopyrimidines, as well as 4,5-dihydroisoxazol-5-ols and pyrazoles were synthesized in moderate to excellent yields. A plausible mechanism was also proposed for the cascade reaction. This method represents an effective strategy towards the synthesis of unsymmetrical 2-aminopyrimidines.
Synthesis, docking, machine learning and antiproliferative activity of the 6-ferrocene/heterocycle-2-aminopyrimidine and 5-ferrocene-1H-Pyrazole derivatives obtained by microwave-assisted Atwal reaction as potential anticancer agents
Antoniazi, Mariana K.,Filho, Eclair Venturini,Greco, Sandro J.,Loureiro, Laiza B.,Pessoa, Claudia,Pina, Jorge W. S.,Pinheiro, Carlos B.,Ribeiro, Marcos A.,Taranto, Alex G.,Guimar?es, Celina J.,de Oliveira, Fátima C. E.
, (2021/07/13)
A simple and fast methodology under microwave irradiation for the synthesis of 2-aminopyrimidine and pyrazole derivatives using Atwal reaction is reported. After the optimization of the reaction conditions, eight 2-aminolpyrimidines containing ferrocene a
Structural identification of pyrazoles and pyrimidines using 2D HMBC NMR and single-crystal X-ray diffraction
Al-Bogami
, p. 4611 - 4614 (2015/11/28)
A facile and highly efficient microwave-assisted synthesis of functionalized pyrazoles and pyrimidines based on the regiospecific synthesis is reported. The present work provides unambiguous evidence of the pyrazoles was determined using 2D HMBC NMR. The structure for pyrimidine have been confirmed by single-crystal X-ray diffraction.
Synthesis of thiophene-linked pyrimidopyrimidines as pharmaceutical leads
Siddesh,Padmashali, Basavaraj,Thriveni,Sandeep
, p. 821 - 826 (2014/07/07)
Thiophene-substituted chalcones were cyclised with guanidine in the presence of potassium hydroxide to get 4-substituted-6-thiophenopyrimidines 2a-e which were then refluxed with acetylacetone to obtain pyrimidopyrimidines 3a-e. Compounds 2a-e were also refluxed with ethylacetoacetate to afford pyirmidopyirimidines 4a-e which on refluxing with POCl3 in presence of DMF produced compounds 5a-e. Nucleophilic substitution reactions on 5a-e were carried out with aniline to obtain 6a-e. The structures of the newly synthesised compounds have been confirmed by elemental analysis and spectral studies. Some selected compounds have been screened for antibacterial and analgesic activities.
Microwave-assisted synthesis of 2-aminopyrimidines from silica gel-adsorbed propargyl alcohols and guanidine
Chen, Qing-Zhen,Ding, Zong-Cang,Ma, Yan-Li,Wang, Zhen-Dong,Zhan, Zhuang-Ping
experimental part, p. 1891 - 1896 (2012/08/28)
A novel methodology toward the synthesis of 2-aminopyrimidines has been developed. The silica gel adsorbed propargyl alcohols and guanidine easilygive the corresponding 2-aminopyrimidines under microwave irradiation.
Microwave-assisted synthesis and anti-bacterial activity of some 2-Amino-6-aryl-4-(2-thienyl)pyrimidines
Chandrasekaran,Nagarajan
, p. 279 - 282 (2007/10/03)
Some novel 2-amino-6-aryl-4-(2-thienyl)pyrimidines were synthesized from 3-aryl-1-thien-2ylprop-2-en-1-ones and guanidine hydrochloride in presence of alkali by conventional heating in alcoholic medium and microwave heating in solvent-free conditions. The compounds were evaluated for in vitro anti-bacterial activity. The anti-bacterial data revealed that compounds 5a-e had better activity against tested Gram-positive organisms than the reference ciprofloxacin and norfloxacin. However, the compounds were nearly inactive against Gram-negative bacteria. Compounds 5c and e were the most active compounds against Gram-positive bacteria.
