83852-29-3

Upstream product

• 83852-28-2 N,N'-bis(N-(carbobenzyloxy)-L-phenylalanyl)-1,3-diaminopropane 
• 119274-75-8 N,N'-bis(N-(carbobenzyloxy)-L-valyl)-1,3-diaminopropane 
• 63-91-2 L-phenylalanine 
• 3397-32-8 N-(benzyloxycarbonyl)-phenylalanine-N-hydroxysuccinimide ester 
• 109-76-2 Trimethylenediamine 
• 1161-13-3 N-Cbz-L-Phe 
• 119153-87-6 (C₅H₉O₂)C₉H₉NO(O)(CO₂C₂H₅) 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 

Downstream Products

• 119274-66-7 (3S,9S)-3,9-dibenzyl-1,4,8,11-tetraazacyclotetradecane-5,7-dione 
• 1256503-04-4 C₃₈H₅₄N₄O₃ 
• 1256502-95-0 C₅₅H₈₀N₄O₄ 
• 1422450-34-7 C₄₇H₇₈N₆O₄ 
• 1422003-99-3 C₃₁H₄₆N₆O₄ 
• 1422450-32-5 C₃₅H₃₈N₆O₄ 
• 94405-01-3 (2S,10S)-1,11-diphenyl-4,8-diazaundecane-2,10-diamine 

Relevant academic research and scientific papers

Synthesis of a Chiral Dioxo-Cyclam Derived from L-Phenylalanine and its Application to Olefin Oxidation Chemistry

An optically active dioxo-cyclam macrocycle bearing two benzyl side chains derived from phenylalanine has been synthesized; its Ni(II) complex catalyzes the oxidation of olefins using hypochlorite under phase transfer conditions.

A configuration can control the synthesis of 2 - (4 - nitro) butyryl pyridine nitrogen - oxidation method of the (by machine translation)

The invention relates to a configuration can control the synthesis of 2 - (4 - nitro) butyryl pyridine nitrogen - oxygen compounds of the method, comprises the following steps: 1) will be 2 - ene acyl pyridine nitrogen - arrive compound and nitromethane o

Cu2+ recognition by N,N′-benzylated bis(amino amides)

Two new C2-symmetric N,N′-benzylated bis(amino amides) have been synthesised and their interaction with different transition metals studied using a variety of techniques including UV-Vis and CD spectroscopy or ESI-MS. The determination of the c

Copper(ii) complexes of macrocyclic and open-chain pseudopeptidic ligands: synthesis, characterization and interaction with dicarboxylates

Mono- and dinuclear Cu(ii) complexes were prepared with pseudopeptidic open chain and macrocyclic ligands, respectively. They were characterized by UV-vis spectroscopy, EPR, HRMS and X-ray diffraction. The Cu(ii) cation is coordinated by two amines and tw

Highly Diastereo- and Enantioselective Michael Addition of Nitroalkanes to 2-Enoyl-Pyridine N-Oxides Catalyzed by Scandium(III)/Copper(II) Complexes

A C2-symmetric Schiff-base ligand, derived from tridentate-Schiff-base, was developed and successfully applied to the asymmetric Michael addition of nitroalkanes to 2-enoyl-pyridine N-oxides. With this newly catalytic system, an unprecedented diastereoselectivity was obtained in the asymmetric Michael addition of nitroalkanes to 2-enoyl-pyridine N-oxides. In addition, a switch in enantioselectivity was achieved by using this newly catalytic system and our previous catalyst. After a facile reduction, the optically active adduct was converted to a biologically active dihydro-2H-pyrrol 4a. Furthermore, a connection of two tridentate-Schiff-base subunits proved to be an effective strategy in ligand design. Complex chemistry! A C2-symmetric Schiff-base ligand, derived from tridentate-Schiff-base, was developed and successfully applied to the asymmetric Michael addition of nitroalkanes to 2-enoyl-pyridine N-oxides with unprecedented diastereoselectivity (see scheme).

A simple peptidomimetic that self-associates on the solid state to form a nanoporous architecture containing chiral π-channels

The crystal structure of a simple peptidomimetic compound, derived from phenylalanine, shows the formation of a nanoporous architecture containing monodimensional π-channels with the aromatic rings as the exclusive components of the chiral channel walls. The Royal Society of Chemistry 2010.

Silver complexes of peptidomimetic polyazapyridinophanes. The influence of the bonding cavity size and the nature of side chains

Several peptidomimetic macrocycles containing a pyridine spacer and ring sizes ranging from 15 to 17 have been efficiently synthesized starting from valine and phenylalanine. The complexes formed have been investigated by potentiometry and NMR. Log K values show that phenylalanine derivatives 8 are consistently more stable than valine derivatives 7, whilst macrocycles with ring sizes of 16 members are the most appropriate for the complexation. The NMR data, in combination with molecular modeling, allow rationalization of the structure of the complexes formed and the participation of the aromatic rings from the side chain of phenylalanine in π-Ag+ interactions to be discarded. The Royal Society of Chemistry 2006.

Efficient macrocyclization of U-turn preorganized peptidomimetics: The role of intramolecular H-bond and solvophobic effects

Simple peptidomimetic molecules derived from amino acids were reacted with meta- and parabis(bromomethyl) benzene in acetonitrile to very efficiently yield macrocyclic structures. The cyclization reaction does not require high dilution techniques and seems to be insensitive to the size of the formed macrocycle. The analysis of data obtained by 1H NMR, single-crystal X-ray diffraction, fluorescence measurements, and molecular mechanics indicate that folded conformations can preorganize the system for an efficient cyclization. The role played by intramolecular hydrogen-bonding and solvophobic effects in the presence of folded conformations is analyzed.

An efficient β-turn directed cyclization of simple peptidomimetics

Chiral polyaza[n]para- and metacyclophanes are easily assembled starting from the appropriate bis(bromomethyl)arene and diamides obtained from aminoacids and alkylidenediamines. The corresponding ortho-derivatives could not be obtained. Molecular dynamics

Optically Active Difunctionalized Dioxocyclam Macrocycles: Ligands for Nickel-Catalyzed Oxidation of Alkenes

A general synthetic route has been applied to the synthesis of optically active difunctionalized dioxocyclam macrocycles, (3S,9S)-3,9-dialkyl-1,4,8,11-tetraazacyclotetradecane-5,7-diones, and their chiral tetraamine precursors.Macrocycles 2a-c derived fro