843608-53-7

Usage

Uses

Used in Pharmaceutical Industry:
(R)-1-(4-Bromo-phenyl)-2,2,2-trifluoro-ethylamine is used as a key intermediate in the synthesis of enantiomerically pure drugs. Its specific orientation is crucial for the biological activity of the final drug product, ensuring targeted therapeutic effects with minimal side effects.
Used in Agrochemical Industry:
In the agrochemical field, (R)-1-(4-Bromo-phenyl)-2,2,2-trifluoro-ethylamine serves as a building block for the development of novel pesticides and herbicides. Its unique chemical properties contribute to the creation of more effective and environmentally friendly agrochemicals.
Used in Research and Development:
(R)-1-(4-Bromo-phenyl)-2,2,2-trifluoro-ethylamine is utilized in various research applications, including the study of chiral chemistry, asymmetric synthesis, and the development of new methodologies for the synthesis of complex organic molecules. Its unique properties also make it a valuable compound for exploring new chemical reactions and mechanisms.
Used in Material Science:
(R)-1-(4-Bromo-phenyl)-2,2,2-trifluoro-ethylamine's unique chemical and physical properties, such as its reactivity and stability, make it a promising candidate for the development of new materials with specific properties. These materials can be used in various applications, including sensors, catalysts, and advanced materials for electronics and energy storage.

Upstream product

• 16184-89-7 4'-bromo-2,2,2-trifluoroacetophenone 
• 842169-80-6 1-(2,2,2-trifluoro)-1-(4-bromophenyl)ethylimine 
• 842169-79-3 N-[1-(4-bromophenyl)-2,2,2-trifluoroethylidene]-1,1,1-trimethylsilanamine 
• 778565-93-8 1-(4-bromophenyl)-2,2,2-trifluoroethanamine 
• 842169-81-7 1-(4-bromo-phenyl)-2,2,2-trifluoro-1-methoxy-ethylamine 
• 336105-43-2 (1S)-1-(4-bromophenyl)-2,2,2-trifluoroethanamine hydrochloride 
• 1448681-98-8 (N-Z)-N-[(4-bromophenyl)methylene]-(R)-2-methyl-propane-2-sulfinamide 
• 1122-91-4 4-bromo-benzaldehyde 
• 336105-31-8 N-[(1S)-1-(4-bromophenyl)-2,2,2-trifluoro-ethyl]-(R)-2-methyl-propane-2-sulfinamide 
• 336105-24-9 (R)-(-)-N-[(1E)-(4-bromophenyl)methylene]-2-methyl-2-propanesulfinamide 

Downstream Products

• 1448682-02-7 N-[(1S)-2,2,2-trifluoro-1-(4-formylphenyl)ethyl]methanesulfonamide 
• 778565-93-8 (1S)-1-(4-bromophenyl)-2,2,2-trifluoroethanamine 
• 778565-93-8 (R)-1-(4-bromophenyl)-2,2,2-trifluoroethanamine 

Relevant academic research and scientific papers

MALT1 MODULATORS AND USES THEREOF

Provided herein are compounds, compositions, and methods useful for modulating MALT1 and tor treating related diseases, disorders, and conditions.

HETEROCYCLYLAMINO-SUBSTITUTED TRIAZOLES AS MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE

This invention relates to novel compounds and pharmaceutical compositions comprising. Compounds of the invention useful as modulators of Rho-associated protein kinase (ROCK), for example ROCK1 and/or ROCK2 inhibitors. Methods of treatment employing the compounds are also contemplated by the present invention. The compounds of the invention are useful in treating ROCK mediated diseases.

Silver-catalyzed formal [3+2]-cycloaddition of α-trifluoromethylated methyl isocyanides: a facile stereoselective synthesis of CF3-substituted heterocycles

An Ag-catalyzed formal [3+2]-cycloaddition of α-trifluoromethylated methyl isocyanides with polar double bonds has been developed for the facile access to trifluoromethylated oxazolines, imidazolines and pyrrolines under mild conditions. The practicality of this chemistry is demonstrated by the gram-scale synthesis of oxazolines with excellent yields and facile transformations of the formed oxazolines to trifluoromethylated β-amino alcohols in quantitative yields.

COMPOSITIONS AND METHODS FOR INHIBITING BMP

The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.

ACYCLIC CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

N-(2-CYANO HETEROCYCLYL)PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

Provided are compounds of Formula I, a JAK inhibitor, and use thereof for the treatment of JAK-mediated diseases by the application.

CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

GEMINALLY SUBSTITUTED CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

NOVEL BENZYL SULFONAMIDE COMPOUNDS USEFUL AS MOGAT-2 INHIBITORS

The present invention provides compounds of Formula I. Wherein Rl, L, and A are as described herein, or a pharmaceutical salt thereof, processes for preparing the compounds, and methods of treating a condition, such as hypertriglyceridemia, using the comp