846541-57-9

Upstream product

• 41038-35-1 (E)-1-bromo-2-(4-methoxyphenyl)-1,2-diphenylethene 
• 7380-78-1 4-(phenylethynyl)anisole 
• 124-38-9 carbon dioxide 
• 1078-58-6 diphenylzinc 
• 72474-39-6 4-(1,2-diphenylvinyl)anisole 
• 24588-72-5 2-(4-methoxyphenyl)-1,3-dithiane 
• 75748-09-3 (4-methoxybenzoyl)trimethylsilane 
• 132274-45-4 2-(4-Methoxyphenyl)-2-(trimethylsilyl)-1,3-dithiane 
• 123-11-5 4-methoxy-benzaldehyde 
• 591-50-4 iodobenzene 

Downstream Products

• 17932-18-2 3-(4-methoxyphenyl)-2-phenyl-1H-inden-1-one 
• 857085-82-6 1-((Z)-1,2-Diphenyl-buta-1,3-dienyl)-4-methoxy-benzene 
• 69967-78-8 (1-(4-methoxyphenyl)but-1-ene-1,2-diyl)dibenzene 
• 857906-52-6 1,2-diphenyl-2-(4-methoxyphenyl)vinyl bromide 

Relevant academic research and scientific papers

Palladium-catalyzed fluoride-free cross-coupling of intramolecularly activated alkenylsilanes and alkenylgermanes: Synthesis of tamoxifen as a synthetic application

We have demonstrated that intramolecular hypercoordination of a carboxylic acid is a powerful activation strategy for the palladium-catalyzed cross-coupling reaction of trialkyl(vinyl)silanes and trialkyl(vinyl)germanes under fluoride-free conditions. Z-β-Trialkylsilyl- and Z-β- trialkylgermylacrylic acids, synthesized stereoselectively by olefination with ynolates, are highly stable and useful reagents for cross-coupling with a variety of aryl iodides to provide tetrasubstituted olefins possessing different carbon substituents in a stereocontrolled and diversity-oriented manner. An application to a stereoselective synthesis of (Z)-tamoxifen is also reported. Copyright

Effective synthesis of tamoxifen using nickel-catalyzed arylative carboxylation

Tamoxifen was synthesized using a nickel-catalyzed arylative carboxylation developed by our group. The key compound, tetrasubstituted alkene, was synthesized from disubstituted alkyne using a catalytic amount of Ni(0) and DBU in the presence of Ph2Zn under an atmosphere of carbon dioxide. The reaction proceeded smoothly in a regio- and stereoselective manner, and the resultant tetrasubstituted alkene was converted into tamoxifen. Georg Thieme Verlag Stuttgart.

Intramolecularly activated vinylsilanes: Fluoride-free cross-coupling of (Z)-β-(trialkylsilyl)acrylic acids

The fluoride-free palladium-catalyzed cross-coupling reaction of trialkyl(vinyl)silanes activated by the intramolecular pentacoordination of carboxylic acid at the Z-β-position is described.