85026-06-8

Basic information

• Product Name: erythro-2-hydroxy-3-methylbutane-1,4-dioic acid
• CAS NO: 85026-06-8
• Molecular Weight: 148.116
• Mol File: 85026-06-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: erythro-2-hydroxy-3-methylbutane-1,4-dioic acid(CAS DataBase Reference)
• NIST Chemistry Reference: erythro-2-hydroxy-3-methylbutane-1,4-dioic acid(85026-06-8)
• EPA Substance Registry System: erythro-2-hydroxy-3-methylbutane-1,4-dioic acid(85026-06-8)

Safety Data

• Hazardous Substances Data: 85026-06-8(Hazardous Substances Data)

Upstream product

• 73840-71-8 diethyl (2S,3R)-(+)-2-hydroxy-3-methylsuccinate 
• 100806-42-6 (E)-(2S,3S)-3-Hydroxy-2-methyl-hex-4-enoic acid 
• 113564-09-3 (E,2R^*,3S^*)-3-hydroxy-2-methyl-4-hexenoic acid 
• 759-65-9 diethyl oxalpropionate 
• 93504-92-8 2-hydroxy-3-methylbutanedioic acid diethyl ester 
• 63921-06-2 3-methyl-2-oxo-butane-1,4-dioic acid dimethyl ester 
• 642-92-2 D,L-threo-β-methylaspartic acid 
• 50460-80-5 (2S,3R)-2-Hydroxy-3-methylbernsteinsaeure-dimethylester 
• 874646-33-0 diisopropyl (2R,3S)-2-methyl-3-hydroxybutanedioate 

Downstream Products

• 85199-56-0 2-Methyl-3-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-succinic acid dimethyl ester 
• 89497-03-0 (2R,3R)-2-Methyl-3-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-succinic acid dimethyl ester 
• 85249-22-5 (2S,3R)-2-Methyl-3-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyloxy)-succinic acid dimethyl ester 
• 111833-04-6 (2S,3S)-2-Acetoxy-4-benzyloxy-3-methyl-butyric acid methyl ester 
• 111833-00-2 (2S,3S)-4-benzyloxy-2-hydroxy-3-methylbuttersaeure 
• 50460-80-5 dimethyl 2-hydroxy-3-methylbutane-1,4-dioate 
• 50460-80-5 dimethyl 2-hydroxy-3-methylbutane-1,4-dioate 
• 50460-80-5 (2S,3R)-2-Hydroxy-3-methylbernsteinsaeure-dimethylester 
• 5380-37-0 (2S,3R)-2-Hydroxy-3-methyl-succinic acid 
• 5380-36-9 (+)-erythro-3-Methylaepfelsaeure 
• 5380-36-9 (-)-threo-3-Methylaepfelsaeure 
• 5380-37-0 (2S,3S)-2-Hydroxy-3-methyl-succinic acid 

Relevant articles and documents

Preparation of Chiral Substituted Succinic Acids

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N-HYDROXYAMIDE DERIVATIVES AND USE THEREOF

The present invention is related to N-hydroxyamide derivatives of Formula (I) and use thereof, in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.

Electrochemical Oxidation of (S)-Malic-Acid Derivatives: a Route to Enantiomerically Pure Alkylmalonaldehydic Esters

The 3,3-dialkylmalic-acid diesters, prepared by the previously described diastereoselective alkylations through dilithium alkoxide enolates, are saponified to the monoesters containing a free α-hydroxycarboxylic-acid moiety.The monoesters are subjected to electrochemical oxidative decarboxylation in MeOH.If the intermediate monoacids are purified, the malonaldehydic esters (2-formyl-2-alkoxycarboxylates) obtained by this procedure are enantiomerically pure; they have the same structural features, i.e. two enantiotopic functionalized branches on the (persubstituted) stereogenic center, as the well known 3-hydroxy-2-methylpropanoic acid ('Roche acid') which was employed frequently as a starting material for the preparation of either enantiomer of various target molecules.