857040-74-5

Usage

Uses

Due to the lack of specific information on the uses of 1,2-Benzenedicarboxylic acid, 3-amino-, radicalion(1-), it is not possible to list its applications in various industries or for specific purposes based on the provided materials. Further research would be required to determine its potential applications and the reasons for its use in different fields.

InChI:InChI=1/C8H7NO4/c9-5-3-1-2-4(7(10)11)6(5)8(12)13/h1-3H,9H2,(H,10,11)(H,12,13)/p-2

Upstream product

• 641-70-3 3-nitrophthalic acid anhydride 
• 603-11-2 3-nitrophthalic acid 
• 4389-50-8 2-amino-6-methylbenzoic acid 
• 7647-01-0 hydrogenchloride 
• 64-19-7 acetic acid 
• 13506-76-8 2-methyl-6-nitrobenzoic acid 
• 85-44-9 phthalic anhydride 
• 521-31-3 5-amino-2,3-dihydrophthalazine-1,4-dione 
• 2580-78-1 reactive blue 19 
• 34529-06-1 dimethyl 3-aminophthalate 
• 22351-62-8 3-nitro-phthalic acid-1-chloride-2-methyl ester 
• 6744-85-0 2-(methoxycarbonyl)-3-nitrobenzoic acid 
• 40637-78-3 2-methyl-6-nitro-benzoic acid amide 
• 1885-76-3 2-cyano-3-nitrotoluene 

Downstream Products

• 16524-16-6 3-benzoylamino-phthalic acid 
• 20579-79-7 3-amino-N-phenylphthalimide 
• 108620-87-7 4-amino-2-o-tolyl-isoindoline-1,3-dione 
• 108347-27-9 3-(2-Carboxy-2-chloro-ethyl)-phthalic acid 
• 81994-66-3 4-amino-2-(2-diethylaminoethyl)-1H-isoindole-1,3(2H)-dione hydrochloride 
• 106420-89-7 4-amino-2-(2-chloro-phenyl)-isoindoline-1,3-dione 
• 17395-99-2 3-aminophthalic anhydride 
• 866639-19-2 3-iodo-N-(1,1-dimethyl-2-methylthioethyl)-o-carbamoylbenzoic acid 

Relevant academic research and scientific papers

Enzyme-Loaded Hemin/G-Quadruplex-Modified ZIF-90 Metal–Organic Framework Nanoparticles: Bioreactor Nanozymes for the Cascaded Oxidation of N-hydroxy-l-arginine and Sensing Applications

Biocatalytic cascades are challenging to operate in homogeneous solution, where diffusional mass transport hinders efficient communication between the reactive components. There is great interest in developing devices to perform such transformations in co

ISOINDOLE DERIVATIVE

Disclosed is a compound of formula (I) and a stereoisomer thereof: wherein R1, R2, R3 and R4 are as defined in the present disclosure.

Visible-Light-Mediated Dearomatisation of Indoles and Pyrroles to Pharmaceuticals and Pesticides

Dearomatisation of indole derivatives to the corresponding isatin derivatives has been achieved with the aid of visible light and oxygen. It should be noted that isatin derivatives are highly important for the synthesis of pharmaceuticals and bioactive compounds. Notably, this chemistry works excellently with N-protected and protection-free indoles. Additionally, this methodology can also be applied to dearomatise pyrrole derivatives to generate cyclic imides in a single step. Later this methodology was applied for the synthesis of four pharmaceuticals and a pesticide called dianthalexin B. Detailed mechanistic studies revealed the actual role of oxygen and photocatalyst.

Synthesis method of methyl 2-acetyl-6-aminobenzoate

The invention provides a synthesis method of methyl 2-acetyl-6-aminobenzoate. The target product methyl 2-acetyl-6-aminobenzoate is prepared from cheap and easily available 3-nitrophthalic acid through a six-step reaction. The synthesis method has the characteristics of easily available raw materials, short route, high yield, easiness in operation, small environmental pollution and the like, and is suitable for large-scale industrial production.

Palladium Supported on Carbon Nanoglobules as a Promising Catalyst for Selective Hydrogenation of Nitroarenes

The catalysts 1?wt% palladium supported on carbon nanoglobules (CNGs) were shown to be highly active in the liquid-phase hydrogenation of various nitroarenes and provided nearly 100% selectivity to aromatic amines at complete conversion under mild conditions (323?K, 0.5?MPa, 1?h). The catalytic activity (in terms of turnover frequency and substrate conversion) and selectivity depend on the kind of CNGs support, catalyst preparation method and the reaction conditions (solvent nature). The Pd/CNGs catalyst can be repeatedly used while maintaining the same catalytic performance. The excellent performances of Pd/CNGs catalysts can be due to the globular morphology of the supports as well as the absence of micropores and pronounced surface defects. Graphic Abstract: [Figure not available: see fulltext.]

METHODS FOR THE TREATMENT OF OBESITY USING APREMILAST

Methods of treating, managing or preventing obesity and overweight are disclosed. Specific methods encompass the administration of apremilast, alone or in combination with additional active agents or treatment regimens.

APREMILAST FOR THE TREATMENT OF A LIVER DISEASE OR A LIVER FUNCTION ABNORMALITY

Methods of treating, managing or preventing liver disease are disclosed. Specific methods encompass the administration of apremilast, alone or in combination with additional active agents or treatment regimens.

NOVEL PROCESS TO PREPARE N-[2-[(1S)-1-(3-ETHOXY-4-METHOXYPHENYL)-2-(METHYLSULPHONYL) ETHYL]-1, 3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-4-YL]ACETAMIDE

An alternative and improved process for the preparation of Apremilast (Formula I) and Apremilast form B or a pharmaceutically acceptable salt thereof is provided. The novel process includes hydrogenation in acetone, Cyclization and acetylation followed by condensation in methyl isobutyl ketone (MIBK) and acetic acid mixture in specific volume ratios.

NOVEL PROCESS FOR PREPARATION OF APREMILAST

The present invention related to a novel compound of Formula II, its enantiomers or acid addition salts thereof and process for its preparation. The compound of Formula II can be used for preparation of N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2- (methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide also known as apremilast.

Visible-light photocatalytic activity of chitosan/polyaniline/CdS nanocomposite: Kinetic studies and artificial neural network modeling

Chitosan/polyaniline (CS/PAni), chitosan/CdS (CS/CdS) and chitosan/polyaniline/CdS nanocomposite were synthesized and characterized using X-ray diffraction pattern analysis, FT-IR spectroscopy and scanning electronic microscopy. The adsorption performance and photocatalytic activity of CS/PAni/CdS was compared with CS/PAni and CS/CdS in the removal of Reactive Blue 19 (RB19) dye. After five cycles of experiments under visible light irradiation, CS/PAni/CdS retained high photocatalytic activity which confirmed good stability of nanocomposite. Moreover, the kinetics of decolorization was investigated and novel equation rate for dye removal was established by considering two parallel mechanisms including adsorption and surface photocatalytic degradation of dye by CS/PAni/CdS. Artificial neural network was employed to develop a model for predicting the decolorization efficiency and determining the relative importance of operational parameters. A 3-layer perceptron network with optimized 5:10:1 topology could provide adequate predictive performance (R2 = 0.983). Moreover, the photocatalytic degradation of RB19 was monitored by measuring the total organic carbon (TOC) and GC-MS analysis, enabling the evaluating the mineralization and identifying the intermediates. During 120 min of experiment, more than 80% of TOC was removed.