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EMD 534085, also known as DAPT, is a potent and selective inhibitor of γ-secretase. It is widely used in research to study the role of γ-secretase in various biological processes, including the processing of amyloid precursor protein and the generation of amyloid beta peptides, which are implicated in the pathogenesis of Alzheimer's disease. Its ability to modulate the activity of γ-secretase makes EMD 534085 a valuable tool for understanding the molecular mechanisms underlying Alzheimer's disease and other neurodegenerative disorders, as well as for the development of potential treatments.

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  • 858668-07-2 Structure
  • Basic information

    1. Product Name: EMD 534085
    2. Synonyms: EMD 534085;N-[2-(Dimethylamino)ethyl]-N'-[[(2R,4aS,5R,10bS)-3,4,4a,5,6,10b-hexahydro-5-phenyl-9-(trifluoromethyl)-2H-pyrano[3,2-c]quinolin-2-yl]methyl]urea
    3. CAS NO:858668-07-2
    4. Molecular Formula: C25H31F3N4O2
    5. Molecular Weight: 476.5344496
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 858668-07-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 609.5±55.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.195
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 13.78±0.46(Predicted)
    10. CAS DataBase Reference: EMD 534085(CAS DataBase Reference)
    11. NIST Chemistry Reference: EMD 534085(858668-07-2)
    12. EPA Substance Registry System: EMD 534085(858668-07-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 858668-07-2(Hazardous Substances Data)

858668-07-2 Usage

Uses

Used in Pharmaceutical Research:
EMD 534085 is used as a research tool for studying the role of γ-secretase in various biological processes and its potential therapeutic applications in Alzheimer's disease and other neurodegenerative disorders.
Used in Alzheimer's Disease Research:
EMD 534085 is used as a selective inhibitor of γ-secretase to investigate its role in the processing of amyloid precursor protein and the generation of amyloid beta peptides, which are implicated in the pathogenesis of Alzheimer's disease.
Used in Neurodegenerative Disorder Research:
EMD 534085 is used as a valuable tool for understanding the molecular mechanisms underlying neurodegenerative disorders and for the development of potential treatments.
Used in Drug Development:
EMD 534085 is used as a starting point for the development of potential treatments for Alzheimer's disease and other neurodegenerative disorders by modulating the activity of γ-secretase.

Check Digit Verification of cas no

The CAS Registry Mumber 858668-07-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,8,6,6 and 8 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 858668-07:
(8*8)+(7*5)+(6*8)+(5*6)+(4*6)+(3*8)+(2*0)+(1*7)=232
232 % 10 = 2
So 858668-07-2 is a valid CAS Registry Number.

858668-07-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[[(2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl]methyl]-3-[2-(dimethylamino)ethyl]urea

1.2 Other means of identification

Product number -
Other names UNII-AL67QX8036

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:858668-07-2 SDS

858668-07-2Downstream Products

858668-07-2Relevant articles and documents

Optical Control of Mitosis with a Photoswitchable Eg5 Inhibitor

Impastato, Anna C.,Shemet, Andrej,Vep?ek, Nynke A.,Saper, Gadiel,Hess, Henry,Rao, Lu,Gennerich, Arne,Trauner, Dirk

, (2022/01/20)

Eg5 is a kinesin motor protein that is responsible for bipolar spindle formation and plays a crucial role during mitosis. Loss of Eg5 function leads to the formation of monopolar spindles, followed by mitotic arrest, and subsequent cell death. Several cell-permeable small molecules have been reported to inhibit Eg5 and some have been evaluated as anticancer agents. We now describe the design, synthesis, and biological evaluation of photoswitchable variants with five different pharmacophores. Our lead compound Azo-EMD is a cell permeable azobenzene that inhibits Eg5 more potently in its light-induced cis form. This activity decreased the velocity of Eg5 in single-molecule assays, promoted formation of monopolar spindles, and led to mitotic arrest in a light dependent way.

PROCESS FOR PREPARING TETRAHYDROQUINOLINE DERIVATIVES

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Page/Page column 34-36, (2009/07/18)

The invention relates to a novel process for preparing enantiomerically enriched or pure tetrahydroquinoline derivatives by reacting a chiral dihydropyran-methylamine C with a aldehyde B and an aniline A in a multicomponent one pot synthesis in the presen

POLYMORPHIC FORMS AND PROCESS

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Page/Page column 30, (2008/06/13)

The invention relates to a process for the manufacture of enantiomerically enriched or pure compounds of formula (I) wherein R1, R2, R3, R6, R7 and Q are defined as in claim 1 as well as their crystal

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