863675-87-0

Upstream product

• 66224-66-6 adenine 
• 350-46-9 4-Fluoronitrobenzene 
• 912539-32-3 [4-(5-amino-4-cyano-imidazol-1-yl)-phenyl]-carbamic acid tert-butylester 
• 100-00-5 4-chlorobenzonitrile 
• 106-40-1 4-bromo-aniline 
• 540-37-4 p-aminoiodobenzene 
• 21314-05-6 9-(4-nitrophenyl)adenine 
• 912539-33-4 C₁₆H₁₈N₆O₂ 

Downstream Products

• 925899-72-5 1-[4-(6-aminopurin-9-yl)phenyl]-3-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)urea 

Relevant academic research and scientific papers

Aromatic diamine containing adenine structure, preparation method of aromatic diamine, polyimide containing adenine structure and preparation method of polyimide

The invention discloses aromatic diamine containing an adenine structure, a preparation method of aromatic diamine, polyimide containing the adenine structure and a preparation method of polyimide. Non-toxic and harmless adenine is taken as a raw material, and a large quantity of bio-based monomers capable of being used for polymer synthesis can be derived, so that an obtained polymer meets the resource saving requirements for sustainable development. A new way based on biomass is provided for the monomer source of polyimide, and the dependency degree of a polyimide material on petroleum resources is relieved.

Direct Arylation of Adenine by Fluoro-and Chloronitrobenzenes: Effect of Microwaves

Direct arylation of adenine with fluoro-and chloronitrobenzenes leads to mixtures of N9 and N7 substituted adenines. After separation by column chromatography, the individual isomers can be efficiently hydrogenated on Pd to give the corresponding aminophenyladenines. A significant enhancement of the reaction rate by microwave irradiation was observed. This two-step procedure was found to be a feasible route to otherwise hardly available 7- aminophenyladenines. Correlation between calculated shielding constants and experimental values of chemical shifts in 13C and 15N NMR was used for assignment of the site of substitution. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]

Direct N9-arylation of purines with aryl halides

An efficient method for N-arylation of purines is reported. The N-arylation is catalysed by Cu(i) and 4,7-bis(2-hydroxyethylamino)-1,10-phenanthroline (BHPhen) in aqueous DMF or ethanol. The reaction generally proceeds with high selectivity for the N

PURINE DERIVATIVES AS RECEPTOR-TYROSINE KINASE ACTIVITYINHIBITORS

The invention relates to compounds of formula (I), whereon R1, R2, R3, R4 and X have the meanings cited in claim 1, are inhibitors of tyrosine kinases, in particular TIE-2, and the Raf-kinases and can be also be used for treating tumours.

HETEROARYLPHENYLUREA DERIVATIVE

The present invention provides a compound represented by the formula (1): wherein R 1 , R 2 and R 5 are each independently selected from a hydrogen atom, a halogen atom, a C 1 -C 6 alkyl is substituted with a halogen atom and the like; R 3 and R 4 are each independently selected from a hydrogen atom, a halogen atom, a substituted C 1 -C 6 alkyl group and the like; R 6 and R 7 are each independently selected from a hydrogen atom and a halogen atom; Z 1 and Z 2 are each independently selected from a hydrogen atom, a hydroxyl group and -O(CHR 11 )OC(=O)R 12 ; Q is a group of the formula: (wherein G 1 is C-Y 2 or N; a ring A is a benzene ring or a 5- to 6-membered unsaturated heterocycle) a pharmaceutically acceptable salt thereof or a prodrug thereof.