864272-34-4

Basic information

• Product Name: 2-Pyridinecarboxamide, N-methyl-4-(4-nitrophenoxy)-
• CAS NO: 864272-34-4
• Molecular Formula: C13H11N3O4
• Molecular Weight: 273.248
• Mol File: 864272-34-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-Pyridinecarboxamide, N-methyl-4-(4-nitrophenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboxamide, N-methyl-4-(4-nitrophenoxy)-(864272-34-4)
• EPA Substance Registry System: 2-Pyridinecarboxamide, N-methyl-4-(4-nitrophenoxy)-(864272-34-4)

Safety Data

• Hazardous Substances Data: 864272-34-4(Hazardous Substances Data)

Upstream product

• 100-00-5 4-chlorobenzonitrile 
• 68559-40-0 3-hydroxypyridine potassium salt 
• 53750-66-6 4-chloro-pyridine-2-carbonyl chloride 
• 1184827-15-3 4-(4-nitrophenoxy)picolinic acid 
• 74-89-5 methylamine 
• 100-02-7 4-nitro-phenol 
• 6144-78-1 N-methylpyridine-2-carboxamide 
• 98-98-6 2-Picolinic acid 
• 5470-22-4 4-chloropicolinic acid 
• 220000-87-3 4-chloro-N-methylpicolinamide 

Downstream Products

• 284461-73-0 sorafenib 
• 284462-37-9 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide 

Relevant articles and documents

Preparation and application of 2-pyridine carboxamide compound

The invention relates to a 2-pyridine carboxamide derivative as shown in a formula I, and pharmaceutically acceptable salt, hydrate, solvate and prodrug thereof. Substituents R1, R2, X and Y have themeanings given in the description. The invention further relates to a compound in the general formula I, and the compound has the strong inhibition effect on FLT-3; the invention further relates to the applications of the compound, and the pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof to preparation of drugs for treating diseases caused by abnormal high expression of FLT-3kinase, especially the applications to preparation of drugs for treating and/or preventing cancers.

A method for synthesizing intermediate zola non-nepal

The invention discloses a synthesis method for a sorafenib intermediate. The synthesis method comprises the following steps: using N-methyl(4-chlorine-2pyridyl)formamide and p-nitrophenol as raw materials, and conducting etherification reaction and hydrogenation reduction to obtain 4-(4-aminophenoxy)-N-methyl-2-pyridinecarboxamide (a compound 1). The yield of 4-(4-aminophenoxy)-N-methyl-2-pyridinecarboxamide obtained according to the synthesis method is 80% or above, the yield of the sorafenib intermediate is 90% or above, and the synthesis process is simple and easy to control, and suitable for large-scale industrialized production.

SEMICARBAZIDE DERIVATIVES AS KINASE INHIBITORS

The present invention relates to semicarbazide derivatives of formula I, the use of the compounds of formula I as inhibitors of one or more kinases, the use of the compounds of formula I for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.